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Nov 2021 DOI 10.14302/issn.2641-4538.jphi-21-3993
Oluwatoyin Adenike Adeyemo-SalamiCorresponding author
Chlorogenic acid (CA), abundantly found in green coffee beans, is a phenolic compound with antioxidant and anti-inflammatory properties amongst others. Exposure to rotenone, a natural pesticide, induces Parkinsonism (a type of neurodegeneration) through the induction of mitochondria dysfunction and…
Dec 2020 DOI 10.14302/issn.2577-2279.ijha-20-3634
Adeshina Oloruntoba AdekeyeCorresponding author
The hippocampus is involved in learning and memory processes, an integral component of cognitive function. The aim of this study is to assess the efficacy of quercetin on manganese-induced neurotoxicity in the hippocampus of the adult mice. In this study, 40 adult mice of average weight of 18 –29g w…
Feb 2017 DOI 10.14302/issn.2574-4372.jesr-16-1380
Huafeng WeiCorresponding author
General anesthetics (GAs) are widely used for various essential surgical or medical procedures. Recent studies implicate the GAs has dual effects of neuroprotection and neurotoxicity on neurogenesis with unclear mechanisms. This minireview summarizes recent studies on GAs mediated effects on neuroge…
Aug 2020 DOI 10.14302/issn.2641-7669.ject-20-3529
Xianjie WenCorresponding author
Background Local anesthetic neurotoxicity is a common complication in clinical anesthesia, which can cause permanent nerve damage in severe cases. The T-type calcium channel is an important channel for regulating the excitability of neurons. Normally, extracellular calcium ions enter the cell throug…
Feb 2014 DOI 10.14302/issn.2328-0182.japst-13-206
J. C. García-RodríguezCorresponding author
The purpose of this study was to investigate the effect of cremophor RH-40 and polysorbate 80 with hydroxypropyl methylcellulose (HPMC) F4M on the development of formulations of intranasal erythropoietin with low sialic acid content (Neuro-EPO) as a neuroprotective agent. Parameters such as pH, osmo…