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Jun 2023
S. Prakasha Gowda A.Corresponding author
Insulin is a frequent peptide hormone addition in serum-free mammalian cell culture media. It contributes in a variety of biological functions, including as promoting cell proliferation, cell cycle progression, and glucose uptake. However, it is unknown how stable insulin is under in vitro cell cult…
Oct 2022 DOI 10.14302/issn.2381-862X.jwrh-22-4315
Anahita NazempourCorresponding author
Background Polycystic ovary syndrome (PCOS) is a serious multifactorial disorder. This study intended to assess the effect of cinnamon supplementation on estradiol level, and fasting- and two-hour (2 hpp) insulin and sugar levels in women with PCOS. Material and Methods This study was a double-blind…
Nov 2018
Ming-Yuh ShiauCorresponding author
Pre-adipocytes are the precursors with the potential to make new fat cells during adipose tissue expansion. Nevertheless, the pre-adipocytes behaviors, and their possible roles in energy homeostasis have long been overlooked. Our previous study implicates that interleukin-4 (IL-4) plays a positive m…
Aug 2017 DOI 10.14302/issn.3070-2313.jeh-17-1552
Belinda ElishaCorresponding author
Introduction. Obesity often coexists with insulin resistance, which is related to cardiometabolic risk. However, some obese individuals exhibit comparable insulin sensitivity (IS) to that of normal-weight subjects, a state associated with a reduced cardiometabolic risk. We aimed to determine the eff…
May 2014 DOI 10.14302/issn.2374-9431.jbd-13-283
Yong MeiCorresponding author
Continuous-time glucose monitoring (CGM) effectively improves glucose control, as oppose to infrequent glucose measurements (i.e. using Lancet Meters), by providing frequent blood glucose concentration (BGC) to better associate this variation with changes in behavior. Currently, the most widely used…
May 2014 DOI 10.14302/issn.2572-3030.jcgb-13-369
Ashraf KhanCorresponding author
Insulin receptor substrate (IRS) 1 and 2 are downstream signaling proteins that influence breast pathophysiology. IRS-1 promotes carcinoma cell proliferation; whereas IRS-2 regulates cell motility, invasion, and glycolysis. Our lab has shown that distinct cellular localization of IRS-2 also plays a…
Dec 2025
Solomon Gebretsadik BerekaCorresponding author
Background Fast food consumption is the major cause of obesity and overweight in worldwide affecting more than 2 billion people, especially developing countries and low income countries. It can lead to hyperinsulinemia and development of insulin resistance, high energy density, high glycemic index,…
Nov 2024 DOI 10.14302/issn.2574-4518.jsdr-24-5271
Rajiv KovilaCorresponding author
Background/Aim Obstructive Sleep Apnea (OSA) is a prevalent disorder characterized by recurrent respiratory disturbances during sleep. Patients with Type 2 Diabetes Mellitus (T2DM) and obesity exhibit a substantial susceptibility to OSA (23%–86%). People with OSA have a high risk of several comorbid…
Aug 2023 DOI 10.14302/issn.2379-7835.ijn-23-4688
Fernando Javier Lavalle-GonzalezCorresponding author
Non-nutritive sweeteners are used as adjuncts in treating patients with diabetes to reduce carbohydrate intake. Monk fruit is an FDA-approved1 natural NNS2-. There is no information regarding the use of monk fruit in individuals with T2DM3. The primary objective was to compare the glycemic response…
Apr 2020 DOI 10.14302/issn.2693-1176.ijgh-20-3269
Seyedeh Nasim HabibzadehCorresponding author
Abdominal obesitywith a big belly is one of the worse type of morbid obesity that is associated with different health failure outcomes. Central obesity leads to an increased risk of health complications such as metabolic syndrome, hypertension, insulin resistance,type 2 diabetes, heart disease and v…
Mar 2020 DOI 10.14302/issn.2374-9431.jbd-20-3195
E.G SergeevaCorresponding author
FIRST St. Petersburg state medical University named after academician I. P. Pavlov
Purpose The goals of the present study were to assess the genotypic and allelic distribution of Bsm-I (rs1544410) and Apa-I (rs7975232) polymorphisms of the vitamin D receptor (VDR) gene in coronary artery disease (CAD) patients in comparison to control patients of the same age without CAD and to de…
Sep 2019 DOI 10.14302/issn.2574-450X.jom-19-3001
Sikandar Hayat KhanCorresponding author
Gene therapy has entered a new era with the dawn of CRISPR/Cas9 technology which though were always available in nature but rediscovered to tame into a real-tlife genome editing tool. With the modernization upsurge and changes in ways the “homo sapiens” survived on this planet from hunger to current…
Jun 2019 DOI 10.14302/issn.2690-0904.ijoe-19-2792
Manfred NeubergerCorresponding author
In deaths and diseases attributed to tobacco smoke cardiovascular events exceed cancer and respiratory diseases. Second hand smoke promotes the development of arteriosclerosis and can trigger acute changes of endothelial function and blood coagulability. Indoor smoking bans reduced coronary syndrome…
Feb 2019 DOI 10.14302/issn.2374-9431.jbd-19-2613
Eman H. RadwanCorresponding author
Diabetes mellitus (DM) is a chronic metabolic disorder. Streptozotocin is a naturally occurring cytotoxic chemical, particularly toxic to the pancreas and insulin producing beta cells in mammals and induces diabetes. Glimepiride is a second generation sulfonylurea, used as second-line or add-on trea…
Jan 2019 DOI 10.14302/issn.2641-5526.jmid-18-2529
Juan Luis Fernández-MartínezCorresponding author
Discrimination of case-control status based on gene expression differences has potential to identify novel pathways relevant to neurodegenerative diseases including Parkinson’s disease (PD). In this paper we applied two different novel algorithms to predict dysregulated pathways of gene expression a…
Jan 2019 DOI 10.14302/issn.2574-450X.jom-18-2484
Eman H. RadwanCorresponding author
Obesity is associated with a number of serious medical complications, which are often referred to as the “insulin resistance syndrome”. The aim of the present study was performed to investigate the possible interaction between a conventional drug used for management of cholesterol and traditional he…
Oct 2017 DOI 10.14302/issn.2381-862X.jwrh-17-1750
Zahra NiknamCorresponding author
Background The prevalence of obesity and type 2 diabetes is escalating at an alarming rate in many developed as well as developing countries. Irisin is a novel muscle and adipose drived chemokine that is, proteolytically processed from the product of the FNDC5 (fibronectin type ш domain containing 5…
Jun 2016
Arup Ratan BandyopadhyayCorresponding author
Earlier studies reported significant association of obesity, hypertension and Type2 Diabetes Mellitus (T2DM). Genetic and many disease-associated alleles have been identified through GWAS and applied to T2DM and indicated roles of renin-angiotensin system (RAS) in insulin signaling pathway and insul…
Jun 2016 DOI 10.14302/issn.2374-9431.jbd-15-647
Asmat NawazCorresponding author
Diabetes is a metabolic disorder that results in human body due to insulin deficiency, insulin resistance or both. In the management of diabetes, glucose monitoring technology has been used for the last three decades. The aim of this review article is to describe concise and organized information ab…
Oct 2014 DOI 10.14302/issn.2471-2140.jaa-14-423
L.S. BilbisCorresponding author
There is increasing evidence of the prevalence manifestations of metabolic syndrome worldwide. Metabolic syndrome is a cluster of abnormalities characterized by hypertension, central obesity, insulin resistance, endothelial dysfunction, dyslipidemia and oxidative stress. All these alterations predis…