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Oct 2026 DOI 10.14302/issn.2379-8572.joa-26-6454
Giorgia GrappeggiaCorresponding author
The clinical use of SCDSF factors in neuro-degenerative pathologies offers a potential therapeutic opportunity. Our observational study aims to evaluate its efficacy in patients affected by Central Vertigo1. A case series divided into two subgroups, all affected by non-migrainous central vertigo, wa…
Feb 2025 DOI 10.14302/issn.2326-0793.jpgr-25-5405
Ming-Fen HoCorresponding author
Alcohol use disorder (AUD) is the most prevalent substance use disorder. Excessive alcohol consumption leads to a range of health issues. We set out to identify inflammatory markers linked to alcohol consumption, which might ultimately offer novel insight into genetic underpinnings and have implicat…
Mar 2024 DOI 10.14302/issn.2689-4602.jes-24-4956
B.F. ChadovCorresponding author
A new type of mutations-dominant lethals with a facultative manifestation -were discovered in D. melanogaster in 2000. These mutations were named conditional mutations. Under restrictive genetic conditions, the mutations manifest themselves as dominant lethals, whereas dominant lethality disappears…
Mar 2022 DOI 10.14302/issn.2692-1537.ijcv-22-4117
Jianqing WuCorresponding author
Several mRNA vaccines are used on the population in the U.S. I started predicting the dangers of mRNA vaccines before March 2021 and update my findings periodically. My prior model study enabled me to identify many flaws in clinical trials, side-effect evaluation methods and mechanism studies, and I…
Oct 2021 DOI 10.14302/issn.2641-5526.jmid-21-3900
Jean-claude PerezCorresponding author
In this theoretical discovery of a law of Life, there is MATHEMATICS (Geometry, Bits and Numbers) that UNIFY 3 universes as complementary as ATOMIC MASS, WAVES, and INFORMATION (DNA, RNA and Amino Acids). The discovery of a simple numerical formula for the projection of all the atomic mass of life-s…
Mar 2020 DOI 10.14302/issn.2575-1212.jvhc-20-3234
Fabrizio di VirgilioCorresponding author
Aim of the Research The aim of this study is to analyze a group of dogs of different breeds affected by osteosarcoma (OSA), to document any prevalence of this primary bone neoplasia in breeds that are phylogenetically close and to help with further research human medicine, as a model of study for pr…
Oct 2019 DOI 10.14302/issn.2372-6601.jhor-19-2986
Isolde RiedeCorresponding author
With the definition of four gene classes, all differences between tumor cells and normal cells can be explained. Proliferative mutations induce a shortcut, forcing the cell to divide. They allow replication without control, induce somatic pairing defects of chromosomes and genome instability. Intact…
Sep 2019 DOI 10.14302/issn.2574-450X.jom-19-3001
Sikandar Hayat KhanCorresponding author
Gene therapy has entered a new era with the dawn of CRISPR/Cas9 technology which though were always available in nature but rediscovered to tame into a real-tlife genome editing tool. With the modernization upsurge and changes in ways the “homo sapiens” survived on this planet from hunger to current…
Feb 2019 DOI 10.14302/issn.2689-4602.jes-18-2431
Boris F ChadovCorresponding author
The existing hypotheses on speciation rely on Mendelian genes and mutations in them. However, genome-wide sequencing demonstrates that the Mendelian genes account less than one-tenth of the entire genome DNA. This means that a greater part of the genome has not yet been subject to large-scale evolut…
Jan 2019 DOI 10.14302/issn.2572-3030.jcgb-18-2527
Xi ZhangCorresponding author
As remarkable advances have been made in immunotherapies, the overall goal of immunotherapy has become the selection of patients and evaluating the benefits of treatment. One of the major obstacles to develop immunotherapies is the lack of effective immune monitoring. Monitoring of key changes in th…
Sep 2018 DOI 10.14302/issn.2641-9467.jgrc-18-2270
Yuan LiCorresponding author
Rice, as one of the most important crops in the world, is facing an ever-accelerating challenge from climate change. Epigenetic modification with its substantially high epimutation rate and the possibility for some epigenetic variation to act as a heritable contributor to crop environmental adaptabi…
Aug 2018 DOI 10.14302/issn.2576-6694.jbbs-18-2173
Nida Tabassum KhanCorresponding author
Bioinformatic tools is widely used to manage the enormous genomic and proteomic data involving DNA/protein sequences management, drug designing, homology modelling, motif/domain prediction ,docking, annotation and dynamic simulation etc. Bioinformatics offers a wide range of applications in numerous…
May 2018
Ioannis AlatsathianosCorresponding author
Genetics alone cannot thoroughly expound the environmental impact on the molecular complexity of the endocrine system. Epigenetic-induced alteration in gene expression has emerged as a way in which environmental compounds may exert endocrine effects. The environmental compounds that interfere with n…
Apr 2018
Jean-claude PEREZCorresponding author
The global analysis of 3 human genomes of increasing levels of evolution (neanderthal / sapiens build34 of 2003 / sapiens hg38 of 2013) reveals 2 levels of numerical constraints controlling, structuring and optimizing the DNA sequences of these genomes. A global constraint - which we will call "HGO"…
Apr 2018 DOI 10.14302/issn.2326-0793.jpgr-18-2004
Pervez AnwarCorresponding author
Human proteome project was revolutionized about 40 years ago with purpose of summarizing whole proteomic data at one place. It was launched after human genome project to map and observe all proteins. The goal related proteomic study is to draft the entire human proteome in disease diagnosis by using…
Feb 2018 DOI 10.14302/issn.2832-5311.jpcd-18-1955
Qian-Hao ZhuCorresponding author
Circular RNAs (circRNAs) are covalently closed single-stranded loop RNA molecules with or without protein coding capability. CircRNAs were previously considered to be splicing intermediates or artifacts but are now found to be pervasively expressed in all eukaryotes studied with some demonstrated to…
Nov 2017 DOI 10.14302/issn.2638-4469.japb-17-1838
Shridhar JambagiCorresponding author
Strawberry powdery mildew, caused by Podosphaeraaphanis is a major fungal disease that affects strawberry yield and quality. In the model plant species Arabidopsis and the crop plants barley, tomato and pea, the Mildew resistance locus O (MLO) proteins have been found to be required for powdery mild…
Oct 2017 DOI 10.14302/issn.2572-5424.jgm-17-1609
Jean-claude PEREZCorresponding author
DUF1220 proteins regions show the largest Homo-Sapiens lineage-specific increase in copy number of any protein-coding region in the human genome and map principally to 1q21.1. DUF1220 deletions have been associated with microcephaly and macrocephaly, respectively. DUF1220 copy number has been linked…
Mar 2017 DOI 10.14302/issn.2326-0793.jpgr-17-1447
Timothy D. HowardCorresponding author
Factors that contribute to the onset of atherosclerosis may be elucidated by bioinformatic techniques applied to multiple sources of genomic and proteomic data. The results of genome wide association studies, such as the CardioGramPlusC4D study, expression data, such as that available from expressio…
Jul 2016 DOI 10.14302/issn.2576-2818.jfb-16-1035
Mayumi SugimotoCorresponding author
Female fertility is an economically important trait in the dairy industry, and the fertility selection index has been developed as a method of including female fertility in the breeding goals of this industry. This index considers a combination of factors, including days open, number of insemination…