Search results for “fluorination”

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Open Access Pub publishes peer-reviewed, free-to-read open-access articles. Showing articles matching fluorination — open any to read the full text, or download the PDF or XML.

1 article
Journal of New Developments in Chemistry Open Access

Syntheses of Clofarabine and Related C2′-β-fluorinated Nucleoside Analogues

Sep 2022 DOI 10.14302/issn.2377-2549.jndc-22-4277
Grigorii SivetsCorresponding author

A multistep synthesis of 2-chloro-9-(2′-deoxy-2′-fluoro-β-D-arabinofuranosyl) adenine (clofarabine) is described from methyl β-D-ribofuranoside. A new improved method for preparation of 1,2-diacetyl D-ribofuranose derivative was developed via acetolysis of tri-O-pivaloylated D-ribofuranoside and pla…

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