Search results for “derivatives”

About 13 results in articles

Open Access Pub publishes peer-reviewed, free-to-read open-access articles. Showing articles matching derivatives — open any to read the full text, or download the PDF or XML.

Selective Cytotoxicity of Damsin Derivatives in Breast Cancer Cells

Apr 2019 DOI 10.14302/issn.2328-0182.japst-19-2759
Olov SternerCorresponding author

Cancer is the leading cause of death worldwide, and there is a constant need for new treatment strategies. Sesquiterpene lactones containing a 3-methylenedihydrofuran-2(3H)-one (or α-methylene-γ-lactone) moiety, for example damsin (1), are Michael acceptors that affect biological processes such as c…

Journal of Enzymes Open Access

Chitin and Chitinases: Biomedical And Environmental Applications of Chitin and its Derivatives

May 2018 DOI 10.14302/issn.2690-4829.jen-18-2043
Palanivel RameshthangamCorresponding author

Disposal of chitin wastes from crustacean shell can cause environmental and health hazards. Chitin is a well known abundant natural polymer extracted after deproteinization and demineralization of the shell wastes of shrimp, crab, lobster, and krill. Extraction of chitin and its derivatives from was…

Chemoenzymatic Synthesis of Purine Modified 3′-deoxy-D-ribonucleosides and Evaluation of Their Antiproliferative Activity

Aug 2026 DOI 10.14302/issn.2377-2549.jndc-26-6392
Grigorii G. SivetsCorresponding author

Chemoenzymatic synthesis of a series of purine modified 3′ deoxyribonucleosides was studied from purine derivatives as acceptors and an excess of 3′-deoxyuridine as the donor, prepared by the chemical deamination of 3′-deoxycytidine, using recombinant uridine and purine nucleoside phosphorylases as…

Synthesis of N-Glycosyl Amides via Hydrolysis of Protected Glycosyl Oxazolines and Ritter-like Reactions of Native Carbohydrates

Jul 2025 DOI 10.14302/issn.2377-2549.jndc-25-5525
Grigorii G. SivetsCorresponding author

A stereoselective synthesis of N-glycosyl amides was studied from available N-glycosyl oxazolines prepared by Ritter-like reactions of protected sugar acetonides. Hydrolysis reactions of the protected pentofuranosyl and hexafuranosyl oxazolines, as precursors of glycosyl amine derivatives, were carr…

Stereoselective Synthesis of N-Glycosyl Oxazolines and Evaluation of Their Antiproliferative Activity

Dec 2023 DOI 10.14302/issn.2377-2549.jndc-23-4740
Grigorii G. SivetsCorresponding author

A stereoselective synthesis of protected N-glycosyl oxazolines has been developed from available acylated sugar 1,2-O-acetonides using intramolecular Ritter-like reactions. New N-α- and β-D-pentofuranosyl, α-D-hexofuranosyl oxazolines as valuable intermediates for preparation of diverse N-glycosides…

Evolutionary Conservation of Hox Genes in Vertebrate Brain Development

Jun 2021 DOI 10.14302/issn.2689-4602.jes-21-3868
Jeffrey O. HendersonCorresponding author

Hox genes, their conserved derivatives, and the pathways responsible for their expression have been extensively studied in the fruit fly, Drosophila melanogaster;the experimentation done in the Drosophila model system has given developmental biologists tools to better understand the role and signifi…

Quantification and Comparison of Opium (Morphine) and Tramadol from Biological Samples "Liquid - Liquid Extraction"

Jul 2020 DOI 10.14302/issn.2377-2549.jndc-20-3413
Ahmed M.A. ShihataCorresponding author

Two analgesic were determined opium (morphine) and tramadol and comparison between two methods of extractions from biological samples. Opium and its derivatives and tramadol are the most commonly used medications for treatment of acute and chronic pain. opium was used as a sedative and hypnotic, but…

RETRACTED: Amino Acid Imbalance in Atherosclerosis

Feb 2020 DOI 10.14302/issn.2379-7835.ijn-20-3188
Nefyodov L.I.Corresponding author Department of Biochemistry Yanka Kupala Grodno State University, Belarus

This article has been retracted on 18 March 2021. VIEW THE RETRACTION NOTICE (https://doi.org/10.14302/issn.2379-7835.ijn-25-5865) A mini-review of literature data on the mechanisms of formation of the stock of free amino acids and their derivatives in atherosclerosis and methods for correcting meta…

Lipid Components in the Dynamin Fraction Prepared from Rat Brain

May 2018 DOI 10.14302/issn.2835-513X.ijl-18-2122
Shohei MaekawaCorresponding author

Membrane dynamics in the presynaptic region of the neuron is a key process of neuronal signal transduction. Dynamin plays a central part during endocytosis participating in the deformation of membrane structure and constriction. During the study of molecular interaction of presynaptic proteins, we f…

Profile of Similarity of Electron Withdrawing Structure Towards Analgesic-Anti-Inflammatory Activity of The Novel Isatin Analogue: Design and Implementation of Phase I Drug Discovery

May 2018 DOI 10.14302/issn.2578-8590.ipj-18-2113
Rahul HajareCorresponding author

Isatin (1H-indole-2,3-dione ) and derivatives demonstrate a diverse array of biological activities. Isatin and 5-halo derivatives has reacted to form the schiff’s bases , mannich bases and friedal craft alkylation’s to form C-C, C-N, C=N bonds. From the spectral studies, isatin has undergoes reactio…

Sulfonamides: Historical Discovery Development (Structure-Activity Relationship Notes)

May 2018
Farah YousefCorresponding author

Sulfonamide group is a magic group introduced as the main core for different bio-activities in drug industry. According to its substitutes, literature divides sulfonamide derivatives to antibacterial sulfonamides and non-anti-bacterial sulfonamides. As Data was collected from different sources such…

Kynurenines and Vitamin B6: Link Between Diabetes and Depression.

Sep 2013 DOI 10.14302/issn.2374-9431.jbd-13-218
Gregory OxenkrugCorresponding author

The increased association between depression and diabetes mellitus is generally acknowledged. Recent studies suggest that depression leads to diabetes.However, the underlying molecular mechanisms for this association remain unclear.Literature and our data indicate that inflammatory and/or stress fac…

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