Search results for “clinical”

About 100 results in articles

Open Access Pub publishes peer-reviewed, free-to-read open-access articles. Showing articles matching clinical — open any to read the full text, or download the PDF or XML.

Carbapenem-resistant Enterobacterales at a quaternary public hospital in Durban, KwaZulu-Natal: Ascertaining the clinical and molecular paradigm shift following COVID-19

Oct 2026 DOI 10.14302/issn.2690-4721.ijcm-26-6425
Nitesh BrijlalCorresponding author

Background Extensive carbapenem use has resulted in an increasing occurrence of difficult-to-treat resistant gram-negative bacteria (DTR-GNB), such as carbapenem-resistant Enterobacterales (CREs). The international antimicrobial resistance (AMR) landscape was profoundly impacted due to varying antib…

The Advantages of Employing the Immune Response Mediated by Immunoglobulins in Preclinical and Clinical Research: An Essential Review

Sep 2026
Yilkal Tariku BelayCorresponding author

Immunoglobulins, commonly known as antibodies, are glycoprotein molecules present on B lymphocytes and within the bloodstream. They are essential components of the immune response, as they detect the harmful molecules of test compounds and stimulate the immune system to manifest proportional counter…

High-Throughput Complex Disease Modeling for Ethical Drug Discovery: Clinical Relevance of a NAM Platform for Cancer Biomarker Development

May 2026 DOI 10.14302/issn.2572-3030.jcgb-26-6307
Arne-C. FaisstCorresponding author

The development of tumor biomarkers derived from blood, or its components, has become pivotal in advancing early cancer diagnosis. Malignant transformations induce cancer-specific alterations in the transcriptome, proteome, and secretome of tumor cells. Recent studies highlighted similar alterations…

Intravascular Laser Irradiation of Blood (ILIB) on Sleep Quality Improvement: A Randomized Placebo-Controlled Clinical Trial

May 2026 DOI 10.14302/issn.2574-4518.jsdr-25-5773
Lucas Peres de SousaCorresponding author

Introduction Sleep quality is a fundamental determinant of human health and well-being. Modified Intravascular Laser Irradiation of Blood (ILIB), a non-invasive therapeutic modality, has emerged as a potential intervention for sleep-related disturbances. Proposed mechanisms include reduced blood vis…

Evaluation of Combined Ultrasonography and Cone Beam Computed Tomography for Clinical Imaging: A Negative Results Study

Feb 2026 DOI 10.14302/issn.2576-6694.jbbs-26-5964
Dennis FlanaganCorresponding author

The combination of ultrasonography (US) and cone beam computed tomography (CBCT) has been proposed as a multimodal imaging strategy capable of uniting realtime softtissue assessment with highresolution threedimensional visualization of osseous structures. This study critically evaluated whether such…

Integrating Analgesic Doses and Pain Trend Analysis: A Novel Clinical Support System

Dec 2025 DOI 10.14302/issn.2688-5328.ijp-25-5402
Shih-Chieh YangCorresponding author

Background Prescribing appropriate analgesics with optimal dosages based on patients' pain severity is challenging, especially when multiple painkillers are involved. Tracking and analyzing the effectiveness of analgesics and their dosages over time is crucial for pain management. Existing systems l…

Caregiver-Child Co-Rumination and Treatment Outcomes in a Randomized Clinical Trial of Rumination-Focused Cognitive-Behavioral Therapy

Nov 2025 DOI 10.14302/issn.2476-1710.jdt-25-5775
Erin A. KaufmanCorresponding author

A number of developmental factors increase risk for adolescent rumination. This particular kind of repetitive negative thinking pattern often begins in the context of familial stressors and parental modeling. Though rumination can be effectively targeted with rumination-focused cognitive behavioral…

A 12-week, Multicenter, Randomized, Double-blind, Placebo-controlled Clinical Trial Evaluating the Efficacy and Safety of DKB-131 in Knee Arthritis

Jun 2024 DOI 10.14302/issn.2379-7835.ijn-24-5117
Do Hoon KimCorresponding author

In this study, the efficacy and safety of DKB-131 (extract of Siraitiagrosvenorii) in adults of both genders presenting mild symptoms of knee arthritis were evaluated in comparison to a placebo. This clinical trial was randomized, double-blind, multicenter, and lasted for 12 weeks. A total of 120 pa…

Edpidemiology, Clinical Profile and Short- Term Outcome of Hypertensive Crisis in N'Djamena (Chad)

Apr 2024 DOI 10.14302/issn.2329-9487.jhc-24-5040
Dangwe Temoua NaibéCorresponding author

Objective Hypertensive crisis is an increasingly frequent medical condition in our context. Its management in medical emergencies is a real challenge for physicians. Few data on hypertensive crisis are available in Chad. The aim of this study was to investigate the epidemiological, clinical and prog…

Antibiotic Prescribing Practices for Upper Respiratory Tract Infection Among Clinical Officers at Kiambu County

Mar 2024 DOI 10.14302/issn.2640-690X.jfm-24-5016
Kevin MurigiCorresponding author

Background Antibiotics are the most prescribed medications worldwide. Global consumption rose by 65% in 76 low and middle-income countries between the years 2000 and 2015. According to the World Health Organization, improper administration of antibiotics occurs in over 60% of people with upper respi…

Molecular Diagnosis in Clinical Management and Diagnosis of Thyroid Cancer

Jan 2024 DOI 10.14302/issn.2574-4496.jtc-23-4835
Abbas Hussein Saleh HusseinCorresponding author

The prevalence of thyroid cancer is rapidly increasing worldwide, majorly due to overdiagnosis and overtreatment methods of differentiated thyroid cancer. The emergent and potent preclinical models, high-throughput molecular techniques, and genetic expression microarrays have delivered deeper insigh…

Rheumatic Heart Disease In Chad: Clinical, Paraclinical, Therapeutic And Progressive Aspects

Dec 2023 DOI 10.14302/issn.2329-9487.jhc-23-4848
Dangwe Temoua NaibeCorresponding author

Introduction Rheumatic heart disease is mostly common in low-income or developing parts of the world, such as Sub-Saharan Africa, with a high morbidity and mortality rate. There are few data that are available in Chad on rheumatic heart disease. Our objective was to study the clinical, echocardiogra…

Clinical application of Momordica charantia (Bitter Melon) for reducing blood sugar in type 2 diabetes mellitus

Oct 2023 DOI 10.14302/issn.2379-7835.ijn-23-4737
Jeremy J. JohnsonCorresponding author

Bitter melon is a popular fruit cultivated in Southeast Asia and other tropical climate regions. Bitter melon has been used in traditional medicine because of its numerous medicinal benefits, including having hypoglycemic effects. This has an indication for diabetic patients, and several clinical tr…

Auricular Vagus Nerve Stimulation Improves Chronic Pain and Pain-Related Cytokine Levels: A Clinical Study

Aug 2023 DOI 10.14302/issn.2688-5328.ijp-23-4624
James AndersonCorresponding author

Periauricular Vagus Nerve Stimulation (pVNS) has been proven safe and effective in reducing chronic pain and related comorbidities in numerous clinical studies. This multicenter, interventional study used a non-randomized, interrupted time-series analysis to test the efficacy of an 8-week treatment…

Journal of Diseases Open Access

Epidemio-Clinical Profile of Acute Diarrhea in Children From 0 To 5 Years and Prevalence of Rotavirus Before and After the Introduction of the Rotasiil Vaccine in the Democratic Republic of Congo.

Jul 2023 DOI 10.14302/issn.2997-1977.jd-23-4588
Freddy Mboko ByamunguCorresponding author

Introduction Acute diarrhea remains one of the major health problems in developing countries. According to the WHO, rotavirus contributes to approximately 40% hospitalizations and is the leading cause of severe diarrhea in children 0-5 years old. The objective was to determine the prevalence of rota…

Abdominal Aortic Aneurysms: Epidemiological, Clinical and Echographic Aspects in The Health Structures of Lomé and At The Kara University Hospital (TOGO)

Jan 2023 DOI 10.14302/issn.2329-9487.jhc-22-4362
Machihude PIOCorresponding author

Objective To describe the epidemiological, clinical and arterial Doppler ultrasound aspects of abdominal aortic aneurysm (AAA). Material and Methods This is a prospective study with descriptive and analytical aims carried out from January 2019 to March 2022 (3 years) at the cardiovascular exploratio…

A Pressure Sensitive Occlusal Contact Indicator for Implant Restorations: An Observational Clinical Evaluation

Dec 2022 DOI 10.14302/issn.2473-1005.jdoi-22-4360
Philip MillsteinCorresponding author

Contact intensity is a significant factor in immoveable implant restorations. This study visually compares the use of four occlusal contact indicators one of which measures contact intensity and surface area in a single subject. The need for an occlusal contact indicator that can be used with fixed…

Evaluation of Cinnamon Supplementation on Insulin Resistance, BMI and Estradiol Levels in Women with Polycystic Ovary Syndrome: A Double-Blinded Randomized Controlled Clinical Trial

Oct 2022 DOI 10.14302/issn.2381-862X.jwrh-22-4315
Anahita NazempourCorresponding author

Background Polycystic ovary syndrome (PCOS) is a serious multifactorial disorder. This study intended to assess the effect of cinnamon supplementation on estradiol level, and fasting- and two-hour (2 hpp) insulin and sugar levels in women with PCOS. Material and Methods This study was a double-blind…

Common Clinical Presentations of GBV Survivors Seen Between 2020-2022 at a GBV Clinic in a Tertiary Care Referral Facility in South East Nigeria

Oct 2022 DOI 10.14302/issn.2381-862X.jwrh-22-4228
U.O Anyanwu,Corresponding author National Obstetrics Fistula Centre, Abakaliki

Background Gender based violence (GBV) refers to any violence targeted at an individual or group on the basis of their gender. It could occur in different forms with several clinical manifestations. The authors have described several clinical manifestations of GBV in a tertiary health centre, knowle…

A Clinical, Electrocardiographic and Echocardiographic Comparison of Patients with Single Vs Multivessel Disease Presenting with Acute Coronary Syndromes

Sep 2022 DOI 10.14302/issn.2329-9487.jhc-22-4252
Rama Kumari NuthalapatCorresponding author

Background Prevalence of coronary artery disease is between 7-13 percent in urban and 2-7 % in rural India1. The alarm in rise in the prevalence of coronary risk factors like diabetes, hypertension, dyslipidemia, smoking, central obesity and physical inactivity2. The correlation between these risk f…

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