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Aug 2026 DOI 10.14302/issn.2377-2549.jndc-26-6392
Grigorii G. SivetsCorresponding author
Chemoenzymatic synthesis of a series of purine modified 3′ deoxyribonucleosides was studied from purine derivatives as acceptors and an excess of 3′-deoxyuridine as the donor, prepared by the chemical deamination of 3′-deoxycytidine, using recombinant uridine and purine nucleoside phosphorylases as…
Jun 2026 DOI 10.14302/issn.2690-4721.ijcm-26-6039
Nidhi RaoCorresponding author
Background Mucormycosis is a rapidly progressive invasive fungal infection associated with high mortality in patients with hematological malignancies such as Acute Lymphoblastic Leukemia(ALL). Early diagnosis is challenging because clinical and radiological findings are often nonspecific, and tissue…
Nov 2021 DOI 10.14302/issn.2377-2549.jndc-21-4017
Grigorii SivetsCorresponding author
Theefficient two-step synthesis of 2-chloro-2′-deoxyadenosine (cladribine) via the anion glycosylation of purine potassium salt with the glycosyl chloride in binary solvent mixtures is described. A new method for preparation of diprotected 2-chloro-6-fluoropurine 2′-deoxy-β- D-riboside was developed…
Dec 2018 DOI 10.14302/issn.2377-2549.jndc-18-2430
John P. Richie JrCorresponding author
Introduction: Analysis of 8-oxodG is usually conducted by either chromatography-based methods or by immunochemical methods commonly used based upon their low cost and high-throughput. However, concern regarding the accuracy of ELISA methods has complicated their use. We directly compare the levels o…
Dec 2015 DOI 10.14302/issn.2471-2140.jaa-15-765
Zaijun ZhangCorresponding author
Reactive oxygen species (ROS) and reactive nitrogen species are believed to be one of the most important culprits in the pathogenesis of cardio/cerebrovascular diseases. Intensive researches have been conducted to target free radicals as potential treatment for cardio/cerebrovascular diseases. The 2…
Jul 2013 DOI 10.14302/issn.2324-7339.jcrhap-12-150
Bineeta KashyapCorresponding author
Aims and Objectives: The incidence of cryptococcal meningitis caused by Cryptococcus neoformans has risen markedly over the past 20 years as a result of theHIV epidemic and increasing use of immunosuppressive therapies. The objectives of this study were to isolate and identify Cryptococcus neoforman…
Apr 2026 DOI 10.14302/issn.2994-6743.ijstd-25-5899
Mark W. RuddockCorresponding author
Background Sexually transmitted infections (STIs) continue to rise globally, with >1 million new cases reported daily in 2020. In England, newly diagnosed STIs increased by 23.8% in 2022 compared to 2021. Many infections remain asymptomatic yet contribute to infertility, pregnancy complications, and…
Oct 2025 DOI 10.14302/issn.3070-3360.ijco-25-5740
Laura Patricia Nava GonzálezCorresponding author
Significance This case report describes the alternative management of hyperuricemia through acupuncture using the Luo Yuan technique. Case presentation A 53-year-old Mexican man was diagnosed with secondary hyperuricemia. The patient began to experience arthralgia in the metatarsophalangeal joint of…
Oct 2025 DOI 10.14302/issn.2329-9487.jhc-25-5726
Rose Okwunu AbahCorresponding author
Background Hypertension in adolescents has been shown to tracks into adulthood, as well as causing premature cardiovascular and renal diseases. Objectives To determine the prevalence of elevated blood pressure and hypertension among adolescents of ages 10-19 years old attending secondary schools in…
Sep 2024 DOI 10.14302/issn.2690-4721.ijcm-24-5126
D. N Girah.Corresponding author
The development of medical therapy and patients profile has led to a rise in the incidence of nosocomial fungal infection. The frequency of candidiasis has surged worldwide, and the prevalent of healthcare diseases are now Candida species. Candida species causes a range of human infections known as…
Nov 2023
Md. Khursid Alam AnsariCorresponding author
Uroscopy is the first documented laboratory test in medicine and is a fundamental diagnostic tool in the Unani system of medicine. Proper sample collection, handling, and identification are important to insure valid results in uroscopy.There are certain do’s and don’ts about the sampling mentioned i…
Sep 2022 DOI 10.14302/issn.2377-2549.jndc-22-4277
Grigorii SivetsCorresponding author
A multistep synthesis of 2-chloro-9-(2′-deoxy-2′-fluoro-β-D-arabinofuranosyl) adenine (clofarabine) is described from methyl β-D-ribofuranoside. A new improved method for preparation of 1,2-diacetyl D-ribofuranose derivative was developed via acetolysis of tri-O-pivaloylated D-ribofuranoside and pla…
Mar 2022
Gudisa BeredaCorresponding author
Dolutegravir suppresses this integration enzyme, so human immune virus can’t create every greater copies of itself, thus ‘’integrase inhibitor.’’ Dolutegravir is hastily absorbed pursuing oral administration. The median maximum plasma concentration is reached 1.5–2.5 hours after oral uptake with a m…
Dec 2020 DOI 10.14302/issn.2329-9487.jhc-20-3611
Yuanan LuCorresponding author
Objective To understand the present status of high blood pressure in Jiangxi adults including the prevalence rate, overall awareness, and hypertension treatment. Methods a total of 7,200 adult participants (over 18 years old) lived in Jiangxi were recruited using a stratified sampling method. Blood…
Jun 2020 DOI 10.14302/issn.2572-3030.jcgb-20-3407
Parviz MahmoudiCorresponding author
Department of Environmental Health Engineering, Air Pollution and Respiratory Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Benzene is known as an environmental and industrial pollutant. One way to check the amount of exposure to benzene is to measure its metabolites in the urine. Trans, Trans-Muconic Acid which is one of its metabolites is also as a biological indicator of exposure to benzene. In this study, the relatio…
Jan 2020 DOI 10.14302/issn.2690-4721.ijcm-19-3154
Metin DOGANCorresponding author
Background The morbidity and mortality associated with the multi drug resistant Gram negative bacterial infections pose a significant and growing challenge to clinical practitioners. Klebsiella pneumoniae, which is a substantial nosocomial pathogen and confer high levels of resistance to broad-spect…
Nov 2019 DOI 10.14302/issn.2641-5518.jcci-19-3098
Caner EdizCorresponding author
Department of Urology, University of Health Sciences (Istanbul), Sultan Abdulhamid Han Education and Research Hospital, Istanbul, Turkey
Idiopathic retroperitoneal fibrosis also known as Ormonds disease is a rare disorder characterized by the development of fibrotic tissue in the retroperitoneum. The fibrotic tissue may compress ureters, leading to obstructive nephrouropathy and renal failure. A 58-year-old man with fatigue, loss of…
Jun 2019 DOI 10.14302/issn.2474-7785.jarh-19-2932
Yvonne Dabota BuowariCorresponding author
Haematuria is a common compliant in the elderly. Microscopic haematuria is first suspected after a dipstick in urine and confirmed with urine microscopy. The causes of haematuria in the elderly may be renal or extra-renal including clotting disorders. This article is a review on haematuria in the el…
Jun 2019 DOI 10.14302/issn.2690-0904.ijoe-19-2792
Manfred NeubergerCorresponding author
In deaths and diseases attributed to tobacco smoke cardiovascular events exceed cancer and respiratory diseases. Second hand smoke promotes the development of arteriosclerosis and can trigger acute changes of endothelial function and blood coagulability. Indoor smoking bans reduced coronary syndrome…
Apr 2019 DOI 10.14302/issn.2324-7339.jcrhap-19-2711
Ahmed M. HusseinCorresponding author
This is cross sectional descriptive community based study to measure the prevalence of Schistosomasis disease, multistage cluster sampling was taken (500person), and the data was collected by the flowing methods, Urine Examination, Stool examination, and Questionnaire, the data was analyzed by using…