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Jan 2022 DOI 10.14302/issn.2372-6601.jhor-22-4061
Anna B. DanilovaCorresponding author
Background Human malignant cell models which reflect the structural and physiological complexity of tumor tissue are of great importance for preclinical research in oncology. Spheroids/tumoroids derived from solid tumors are of great interest as cellular models mimicking the first vascular-free grow…
May 2026 DOI 10.14302/issn.2572-3030.jcgb-26-6307
Arne-C. FaisstCorresponding author
The development of tumor biomarkers derived from blood, or its components, has become pivotal in advancing early cancer diagnosis. Malignant transformations induce cancer-specific alterations in the transcriptome, proteome, and secretome of tumor cells. Recent studies highlighted similar alterations…
Dec 2022 DOI 10.14302/issn.2574-4526.jddd-22-4151
M. DarouichiCorresponding author
Steroid cell tumors of the ovary are particularly rare, secreting sex hormones, characterized by steroid cell proliferation and represent only 0.1% of all ovarian tumors. They are classified into three subtypes according to their cell of origin: stromal luteoma, Leydig cell tumors and a third subtyp…
Feb 2022
Ricardo GobatoCorresponding author
Using samples of small cell lung tumors, a research team led by biologist Dr. Raymond discovered two new ways to induce tumor cell death. By activating ferroptosis, one of two subtypes of tumor cells can be targeted: first, iron-dependent cell death due to oxidative stress, and second, oxidative str…
Feb 2021 DOI 10.14302/issn.2372-6601.jhor-21-3733
Xin QingCorresponding author
Breast implant-associated anaplastic large cell lymphoma (ALCL) is a recently recognized type of T-cell lymphoma that can develop following breast implants, with morphologic and immunophenotypic features indistinguishable from those of ALK-negative ALCL. Here we report a case of a 58-year-old woman…
Jul 2020 DOI 10.14302/issn.2575-1212.jvhc-20-3434
Pamela R.R. MoreiraCorresponding author
Background The mammary glands are the second most common tumor development site in female dogs. One of the ways of staging such tumors is to evaluate the presence or absence of distant metastasis, including in bone marrow. Such findings in human medicine are associated with poor survival of women wi…
Mar 2020 DOI 10.14302/issn.2372-6601.jhor-20-3235
Mahawa Sangaré-BambaCorresponding author
Introduction Acute leukaemia are the clonal and malignant proliferation of immature hematopoietic cells (blast), blocked in their differentiation process. There is an interaction between cancer cells and the clotting process. This could be the expression of Tissue Factor (TF) on the surface of tumor…
Feb 2020 DOI 10.14302/issn.2381-862X.jwrh-19-3143
Pramod Vishwanath PrasadCorresponding author
Emergence of various nanoscale drug carrier platforms as Drug Delivery Systems (DDS) has revolutionized the field of medicine.Nonetheless, theside-effects due to non-specific distribution of anticancer therapeutics in normal, healthy tissues remain to be a prime pitfall in curing cancers. Therefore,…
Dec 2019 DOI 10.14302/issn.2575-1212.jvhc-19-3101
Pamela Rodrigues Reina MoreiraCorresponding author
Papillary carcinoma is a mammary neoplasia of women and female dogs characterized by papillary fibrovascular projections lined by epithelial cells. Evaluation on the biology of these tumors can be done by immunohistochemistry through detection of alpha-smooth muscle actin protein in the papillary my…
Oct 2019 DOI 10.14302/issn.2372-6601.jhor-19-2986
Isolde RiedeCorresponding author
With the definition of four gene classes, all differences between tumor cells and normal cells can be explained. Proliferative mutations induce a shortcut, forcing the cell to divide. They allow replication without control, induce somatic pairing defects of chromosomes and genome instability. Intact…
Mar 2018
Loris RizzelloCorresponding author
The crusade against cancer has a new army: immunotherapy. The rational design is very simple, but brilliant at the same time. Extract the patients T-cells, reprogram them in vitro for the expression of highly specific receptors against cancer, perfuse them back to the patient. As a result, T-cells a…
Jul 2017 DOI 10.14302/issn.2575-1212.jvhc-17-1586
Mayara Caroline ROSOLEMCorresponding author
The mammary tumor is one of the most common cancer in female dogs and, at the present days, there is a big focus on the study of the relation between this kind of tumor in animals and the cells that stay around them, like the inflammatory cells. The objective of this study was to evaluate and show w…
Apr 2017 DOI 10.14302/issn.2372-6601.jhor-17-1463
Sylwia SzablewskaCorresponding author
Melanoma is considered to be a very aggressive cancer due to its rapid growth, early and multiple metastases and limited response to standard treatment. Many researchers have hypothesized that the combination of radiation therapy and immunotherapy in the treatment of melanoma primary tumors and meta…
Feb 2016 DOI 10.14302/issn.2574-4496.jtc-15-838
Daniel ChristopheCorresponding author
Thyroid transcription factor-1 (TTF-1) is known to play key roles in thyroid organogenesis, in thyroid cell proliferation and in the expression of genes involved in thyroid differentiated function. Many human thyroid cancer cell lines keep producing TTF-1 despite the loss of differentiated gene expr…