Search results for “Pathogenesis”

About 22 results in articles

Open Access Pub publishes peer-reviewed, free-to-read open-access articles. Showing articles matching Pathogenesis — open any to read the full text, or download the PDF or XML.

Molecular and Metabolic Pathogenesis of Familial Combined Hyperlipidemia and Association with Metabolic Syndrome

Sep 2019 DOI 10.14302/issn.2572-5424.jgm-19-3024
Sikandar Hayat KhanCorresponding author

Background The objective of this review is to unify the various genetic defects along with elaborating metabolic pathways in Familial Combined Hyperlipidemia(FCHL) and also to differentiate the phenotype of FCHL from metabolic syndrome. Methods PubMed and Cochrane’s library was searched for keyword…

A Review of the Histologic, Genetic and Molecular Characteristics of Meningioma Pathogenesis and Progression

Aug 2017 DOI 10.14302/issn.2572-3030.jcgb-14-383
Adrian MaurerCorresponding author

Meningiomas are the most common intracranial tumor in humans. The heterogeneity of these tumors lends difficulty to the genetic, epigenetic, and molecular changes that occur in meningioma pathogenesis, progression, and recurrence. Current de facto classification schemes are based on histologic evalu…

Bioinformatic Analysis of Coronary Disease Associated SNPs and Genes to Identify Proteins Potentially Involved in the Pathogenesis of Atherosclerosis

Mar 2017 DOI 10.14302/issn.2326-0793.jpgr-17-1447
Timothy D. HowardCorresponding author

Factors that contribute to the onset of atherosclerosis may be elucidated by bioinformatic techniques applied to multiple sources of genomic and proteomic data. The results of genome wide association studies, such as the CardioGramPlusC4D study, expression data, such as that available from expressio…

Haematological Disturbances in Dengue Haemorrhagic Fever - its Pathogenesis and Management Perspectives

Jan 2015 DOI 10.14302/issn.2372-6601.jhor-14-381
Kolitha H SellahewaCorresponding author

Haemorrhage is common to both dengue fever (DF) and dengue haemorrhagic fever (DHF). Thrombocytopaenia is exceedingly common, while prolonged partial thromboplastin time and reduced fibrinogen concentration are the other abnormal haemostatic indices evident from early in the disease course. These ha…

A New Model of Body Composition: Concept and Design Features of the DBA-Model

Apr 2026 DOI 10.14302/issn.2574-450X.jom-26-6138
Nicolaus DahlmannCorresponding author

Indices, based on data such as height and weight in general and in particularly the body mass index (BMI), are often used to assess overweight. However, there is limited capacity to differentiate the amount of fat mass between individuals. This review refers to an anthropometric model called Dahlman…

A Network Pharmacology-Based Strategy For Predicting Therapy Targets Of Beta-Sitosterol In Treating Diabetic Retinopathy

May 2024 DOI 10.14302/issn.2470-0436.jos-23-4493
Kexin SunCorresponding author

Background Beta-Sitosterol (SIT) is an active TCM compound employed to treat diabetic retinopathy (DR). A network pharmacology approach to understanding the active ingredients and the therapeutic mechanisms underlying DR has not been pursued. Methods The potential targets for DM were identified acco…

Content of Copper, Iron, Iodine, Rubidium, Strontium and Zinc in Thyroid Malignant Nodules and Thyroid Tissue adjacent to Nodules

Feb 2022 DOI 10.14302/issn.2689-5773.jcdp-22-4065
Vladimir ZaichickCorresponding author

Thyroid malignant nodules (TMNs) are the most common endocrine cancer. The etiology and pathogenesis of TMNs must be considered as multifactorial. Diagnostic evaluation of TMNs represents a challenge, since there are numerous benign and malignant thyroid disorders that need to be exactly attributed.…

Association of Serum Calcium Level with other Risk Factors of Ischaemic Stroke

Feb 2022
A K Al MirajCorresponding author

Introduction Calcium (Ca2+) plays an important role in the pathogenesis of ischemic cell damage. Intracellular Ca2+ accumulation leads to neuronal damage by triggering the cycle of cytotoxic events, however the relationship of serum Ca levels and the pathways involved in ischemic injury is unclear.…

RETRACTED: Postulation of the Effect of Unpredicted Predisposing Factors for Post-Tonsillectomy Bleeding

Aug 2021 DOI 10.14302/issn.2379-8572.joa-21-3913
Mohamed Bofares KhaledCorresponding author Professor of otorhinolaryngology Omar Almoukhtar University, Elbyda, Libya

This article has been retracted on 20 January 2022. VIEW THE RETRACTION NOTICE (https://doi.org/10.14302/issn.2379-8572.joa-25-5850) Back ground and Objectives Tonsillectomy is the most common surgical procedure in specialty of otorhinolaryngology. Therefore there are frequent premises regarding thi…

A Systematic Review of the Antimony Content of the Normal Human Prostate Gland

Dec 2020 DOI 10.14302/issn.2372-6601.jhor-20-3673
Vladimir ZaichickCorresponding author

The prostate gland is subject to various disorders. The etiology and pathogenesis of these diseases remain not well understood. Moreover, despite technological advancements, the differential diagnosis of prostate disorders has become progressively more complex and controversial. It was suggested tha…

The Location and Diameter of the Primary Maxillary Sinus Ostium in Malaysians: A Cone-Beam Computerized Tomography Study

Feb 2020 DOI 10.14302/issn.2768-0207.jbr-20-3194
Nisreen Mohammed AL-NamnamCorresponding author

Rhinosinusitis is one of widely spread diseases in the region and the role of the anatomical variations in its pathogenesis remains unresolved. A retrospective study using CBCT scan was employed to locate and measure the diameter of 320 primary maxillary ostium (PMO) (n = 160 subjects) among the Mal…

Biological Networks: An Introductory Review

Oct 2018 DOI 10.14302/issn.2326-0793.jpgr-18-2312
Mohammad Saad Zaghloul SalemCorresponding author

All aspects of life activities in living cells are mediated/executed and regulated by a vast number of networks, comprising a wide spectrum of components, starting with simple biomolecules and ending with the whole organism, and functioning within a precisely organized tight framework. Proper mediat…

Advanced Virological And Clinicopathological Studies On Cattle Suffering From Foot And Mouth Disease Virus

Sep 2017 DOI 10.14302/issn.2577-137X.ji-17-1736
Samia Ahmed KamalCorresponding author

Some strains of Foot and mouth disease virus (FMDV) are endemic in Egypt. The present study was performed on cattle and buffaloes (ages: 3 months up to 1.5 years old, of years 2015 and 2016), which were suffering foot and mouth disease (FMD). Sera and tissues samples were tested by different techniq…

Importance of Neutrophil/Lymphocyte Ratio in Squamous-Cell Carcinoma of the Larynx

Jan 2017 DOI 10.14302/issn.2379-8572.joa-16-1399
Muhammet fatih topuzCorresponding author

Aim: The relation between inflammation and cancer has been known since the 19th century. However, investigations on the pathogenesis and pathophysiology of this relation have begun recently. It was demonstrated that increased neutrophil/lymphocyte ratio is a poor prognostic factor in some malignanci…

Primary Malignant Melanoma Of The Parotid Gland Combined 18F-FDGPET/CT And Immunochemical Diagnosis with Literature Review

Nov 2016 DOI 10.14302/issn.2574-4526.jddd-16-1322
Mohammed DarouichiCorresponding author Institute medical radiology

Summary Primary malignant melanoma arising from the parotid gland is extremely rare and only sporadic cases have been described. This entity is characterized by delayed diagnosis, poor prognosis and controversial pathogenesis. We report a case of primary malignant melanoma of the parotid gland in a…

Adenosquamous Cell Carcinoma of the Stomach 18F-FDG PET/CT Diagnosis and Review of Literature

Nov 2016 DOI 10.14302/issn.2574-4526.jddd-16-1311
M DarouichiCorresponding author Department of radiology

Adenosquamous carcinoma of the stomach (ASCS) is extremely rare with less than one hundred cases published in the world literature. It is defined by combined adenocarcima and squamous cells carcinoma of the stomach. ASCS is clinically aggressive and has a poor prognosis, even when discovered at an e…

Radical-Scavenging and Anti-Oxidative Activities of TBN in Cell-Free System and Murine H9c2 Cardiomyoblast Cells

Dec 2015 DOI 10.14302/issn.2471-2140.jaa-15-765
Zaijun ZhangCorresponding author

Reactive oxygen species (ROS) and reactive nitrogen species are believed to be one of the most important culprits in the pathogenesis of cardio/cerebrovascular diseases. Intensive researches have been conducted to target free radicals as potential treatment for cardio/cerebrovascular diseases. The 2…

Tourette’s Syndrome: Medical, Educational and Behavior Therapy

Dec 2015 DOI 10.14302/issn.2474-9273.jbtm-15-794
Mei-Hue WeiCorresponding author

The French physician, Gill de la Tourette, was the first person to define Tourette’s Syndrome (TS) in 1885 and has brought much attention to it in Western countries for the past few decades. Unfortunately, most Asian countries are not familiar with Tourette’s Syndrome. Tourette’s Syndrome is regarde…

The Silver, Cobalt, Chromium, Iron, Mercury, Rubidium, Antimony, Selenium, and Zinc Contents in Human Bone Affected by Chondrosarcoma

Aug 2015 DOI 10.14302/issn.2372-6601.jhor-15-666
Vladimir ZaichickCorresponding author

Objectives: To clarify the role of trace elements in the etiology and the pathogenesis of the chondrosarcoma, a non-destructive neutron activation analysis with high resolution spectrometry of long-lived radionuclides were performed. Methodology: The silver (Ag), cobalt (Co), chromium (Cr), iron (Fe…

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