Search results for “Histochemical”

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P16/INK4a and KI-67 Evaluation of Intraepithelial and Benign Cervical Lesions at the University College Hospital, Ibadan - A Retrospective Immunohistochemically Study

Sep 2017 DOI 10.14302/issn.2572-3030.jcgb-17-1737
J. O OgunbiyiCorresponding author Scientific review, Supervisory, slides evaluation and final review

Objective P16INK4a and Ki-67 are adjuncts to current histological assessment of cervical biopsies in identifying cases that require strict follow up and prompt intervention. This study aimed to evaluate P16INK4a and Ki-67 expression in squamous intraepithelial and other benign cervical lesions. Meth…

Psychological “Risks” of Colonoscopy are Greater Amongst Fecal Immunohistochemical Test Positive Individuals than those with Inflammatory Bowel Disease

Aug 2016 DOI 10.14302/issn.2471-7061.jcrc-14-426
Réme MountifieldCorresponding author

Background: Colorectal cancer (CRC) screening by Fecal Immunohistochemical Testing (FIT) followed by colonoscopy reduces colorectal cancer mortality. Barriers to colonoscopy should be minimised. Objective: To compare psychological “risks” of colonoscopy in FIT positive (FIT+) subjects and those with…

Comparison of Phosphohistone H3 Immunohistochemical Staining, Ki-67, and H&E Mitotic Count in Invasive Breast Carcinoma

Oct 2015
Jennifer S. WooCorresponding author

The mitotic count is the most frequent reason for discordance between pathologists in modified Bloom and Richardson (mBR) scoring. Recently, the phosphohistone H3 (PHH3) immunohistochemical stain has been proposed as a potential surrogate marker for mitotic figures. This study examines the differenc…

COVID-19-Induced Changes in the Fibrin Network of Pulmonary and Renal Microthrombi

Sep 2024 DOI 10.14302/issn.2692-1537.ijcv-24-5218
Cesar Luna-RiveroCorresponding author

Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection often causes coagulation disorders that affect highly vascularized organs, such as the lungs and kidneys. Objective The objective of this study was to report the histopathological findings of variations in the fibrin p…

Lennert Lymphoma (lymphoepithelioid lymphoma) with Extensive Necrosis: A Case Report

Apr 2021 DOI 10.14302/issn.2372-6601.jhor-21-3801
Xin QingCorresponding author

Lennert lymphoma (lymphoepitheloid lymphoma) is an extremely rare variant of peripheral T-cell lymphoma, not otherwise specified. Here we report a case of Lennert lymphoma diagnosed in a 57-year-old woman. She had a three-year history of waxing and waning lymphadenopathy with a rapid increase in siz…

Quercetin Attenuates Manganese-Induced Neurotoxicity in Mice Hippocampus by Regulation of Oxidative Stress and Tumour Necrosis factor Alpha Expression 

Dec 2020 DOI 10.14302/issn.2577-2279.ijha-20-3634
Adeshina Oloruntoba AdekeyeCorresponding author

The hippocampus is involved in learning and memory processes, an integral component of cognitive function. The aim of this study is to assess the efficacy of quercetin on manganese-induced neurotoxicity in the hippocampus of the adult mice. In this study, 40 adult mice of average weight of 18 –29g w…

Investigation of Neoplastic Cells in the Bone Marrow of Female Dogs with Mammary Gland Tumors

Jul 2020 DOI 10.14302/issn.2575-1212.jvhc-20-3434
Pamela R.R. MoreiraCorresponding author

Background The mammary glands are the second most common tumor development site in female dogs. One of the ways of staging such tumors is to evaluate the presence or absence of distant metastasis, including in bone marrow. Such findings in human medicine are associated with poor survival of women wi…

Glandular and Cystic Bladder Cystitis: Case Report and Review of the Literature

Jun 2020 DOI 10.14302/issn.2574-4526.jddd-20-3410
M. DarouichiCorresponding author

Glandular-cystic bladder cystitis is a rare, benign non-tumor condition, preferentially located on the area of the bladder trigone and can simulate a malignant tumor. It is a benign reactive metaplasia of the bladder submucosa, characterized by hyperplasia of the islets of Von Brunn and cystic. It i…

Chondroplasty Efficacy of Bone Matrix

Dec 2019 DOI 10.14302/issn.2577-2279.ijha-19-3110
N.A. KiryanovCorresponding author Izhevsk State Medical Academy, Izhevsk, Russia

Aim To study the chondroplasty efficacy of the bone matrix obtained using an original technology in restoring cartilage defect of the knee joint. Material and Methods Marginal defects were modeled on the surface of the distal end of the femur in 40 adult male Wistar rats. The bone matrix obtained us…

Immunodetection of Leishmania Infantum in the Subungual Area of Dogs with Visceral Leishmaniasis

May 2019 DOI 10.14302/issn.2575-1212.jvhc-19-2722
Pamela Rodrigues Reina MoreiraCorresponding author

Onychogryphosis is one of the main clinical findings in dogs with visceral leishmaniasis (VL); however, research focusing on the subungual area of infected dogs is scarce. This study aims to assess the subungual area of dogs with VL that presented or not onychogryphosis by means of histopathological…

Changes in Rats’ Liver Structure Induced by Zinc Oxide Nanoparticles and the Possible Protective Role of Vitamin E

Oct 2018 DOI 10.14302/issn.2577-2279.ijha-18-2384
Abdelmonem A. HegazyCorresponding author

Background: Oral ingestion of zinc oxide nanoparticles (ZnONPs) may lead to serious liver injury. Vitamin E (VE) is an important antioxidant factor that can reduce such damage. Aim: This study aimed to evaluate the possible changes that could take place in the liver of adult male albino rats after o…

Acute and Chronic Wound Fluid Inversely Influence Wound Healing in an in-Vitro 3D Wound Model

Dec 2017 DOI 10.14302/issn.2640-6403.jtrr-17-1818
Manuela BesserCorresponding author University Witten/Herdecke, Centre for Biomedical Education and Research (ZBAF), Dpt. Of Translational Wound Research

If a wound progressively heals or the healing process is impaired is basically influenced by the surrounding milieu. This is reflected by the wound fluid. Its specific composition triggers the migration, proliferation and differentiation of dermal and epidermal cells which so far was not sufficientl…

The 5-HT1A Agonist Buspirone Decreases Liver Oxidative Stress and Exerts Protective Effect Against CCl4– Toxicity

Dec 2017 DOI 10.14302/issn.2641-7669.ject-17-1789
M.E.Abdel-Salam OmarCorresponding author Departments of Toxicology and Narcotics

We aimed to study the effect of buspirone, an anxiolytic drug and 5-HT1A agonist on liver injury induced by carbon tetrachloride (CCl4) in rats. Rats were orally treated with CCl4 (2.8 mL/kg in olive oil) along with buspirone at 10, 20 or 30 mg/kg once daily starting with CCl4 and for one week there…

Protective Effect of Fennel Oil on Cyclophosphamide Inhibited Spermatogenesis and Induced Oxidative Stress in Albino Rats.

Oct 2017 DOI 10.14302/issn.2576-6694.jbbs-17-1742
Saber A. SakrCorresponding author

Introduction: Cyclophosphamide (CPA) is an anticancer drug .Fennel (Foeniculum vulgare Mill) essential oil is a traditional medicine used against many diseases. Aim. The present work studied the effect of fennel oil against testicular damage and oxidative stress induced by the anticancer drug, cyclo…

Relationship Between Inflammatory Infiltrate Canine Mammary Carcinomas.

Jul 2017 DOI 10.14302/issn.2575-1212.jvhc-17-1586
Mayara Caroline ROSOLEMCorresponding author

The mammary tumor is one of the most common cancer in female dogs and, at the present days, there is a big focus on the study of the relation between this kind of tumor in animals and the cells that stay around them, like the inflammatory cells. The objective of this study was to evaluate and show w…

Thymic Hypertrophy and Sudden Unexpected Death In Adults –A Retrospective Study Of 56 Autopsy Cases

Jul 2017 DOI 10.14302/issn.2577-2279.ijha-17-1538
Liping ZouCorresponding author

Status thymico-lymphaticus had ever been explained as a cause of sudden death usually in children, but few cases were reported in adults. We sought to determine the relationship between thymic hypertrophy and sudden unexpected death in adult (SUDA), and associated macroscopic and microscopic finding…

Transiently Raised IOP Equivalent to That Experienced During Ocular Surgery Causes Moderate Inflammation but does not Affect Retinal Function or Result in Retinal Ganglion Cell Loss in An Animal Model

May 2017 DOI 10.14302/issn.2470-0436.jos-17-1453
Jie ZhangCorresponding author

Purpose: High intraocular pressure (IOP) is known to result in retinal ganglion cell (RGC) loss, both with chronically raised intraocular pressure (such as with glaucoma) and with acute raises in pressure (due to injury or acute angle closure). Because IOP is often raised during ocular surgery, the…

Primary Malignant Melanoma Of The Parotid Gland Combined 18F-FDGPET/CT And Immunochemical Diagnosis with Literature Review

Nov 2016 DOI 10.14302/issn.2574-4526.jddd-16-1322
Mohammed DarouichiCorresponding author Institute medical radiology

Summary Primary malignant melanoma arising from the parotid gland is extremely rare and only sporadic cases have been described. This entity is characterized by delayed diagnosis, poor prognosis and controversial pathogenesis. We report a case of primary malignant melanoma of the parotid gland in a…

Adenosquamous Cell Carcinoma of the Stomach 18F-FDG PET/CT Diagnosis and Review of Literature

Nov 2016 DOI 10.14302/issn.2574-4526.jddd-16-1311
M DarouichiCorresponding author Department of radiology

Adenosquamous carcinoma of the stomach (ASCS) is extremely rare with less than one hundred cases published in the world literature. It is defined by combined adenocarcima and squamous cells carcinoma of the stomach. ASCS is clinically aggressive and has a poor prognosis, even when discovered at an e…

Diagnostics of Progressive Multifocal Leukoencephalopathy in a Patient with Concomitant Lymphoma Infiltration of Central Nervous System During R-CHOP Chemotherapy- A Case Presentation and Review of the Literature.

Jun 2014 DOI 10.14302/issn.2372-6601.jhor-14-378
Monika Kulma-KreftCorresponding author

Progressive multifocal leukoencephalopathy (PML) is a rare complication associated, inter alia, with rituximab-based lymphoma treatment. PML diagnosis is made easier with the criteria recently published by the American Academy of Neurology. Unambiguous diagnosis of PML can be achieved by demonstrati…

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