Search results for “Animal model”

About 16 results in articles

Open Access Pub publishes peer-reviewed, free-to-read open-access articles. Showing articles matching Animal model — open any to read the full text, or download the PDF or XML.

Learning and Memory in an Animal Model of Longevity: The Ames Dwarf Mice

Oct 2025 DOI 10.14302/issn.3070-2313.jeh-25-5757
David P. AustinCorresponding author

The Ames dwarf mice have a recessive mutation of the PROP-1 gene that produces hereditary dwarfism. The abnormality is responsible for an anterior-pituitary deficiency that results in a substantial reduction of growth hormone, thyroid-stimulating hormone, and prolactin. These mice are smaller in siz…

Histo-Morphological Effect of The Small, Large Intestines and Stomach of Animal Models Treated With Aqueous Extract of Abelmoschus Esculentus

Nov 2022 DOI 10.14302/issn.2641-4538.jphi-22-4235
Kebe E. ObetenCorresponding author

This study investigates the effect of Aqueous extract of abelmoschus esculentus on the microanatomy of the small, large intestine and stomach and the body weight of Wister rats. Twenty-one adults male wistar rats weighing between 100-120 grams were assigned into three groups consisting of seven rats…

Effect of the Biofield Energy Treated Proprietary Test Formulation for Sleep Biomarkers in the Unpredictable Chronic Stress (UCS) Animal Model 

Jan 2020 DOI 10.14302/issn.2474-9273.jbtm-19-3157
Snehasis JanaCorresponding author

Sleep biomarkers in brain such as melatonin, BDNF (Brain-derived neurotrophic factor), PGD2 (Prostaglandin D2), leptin, orexin-A, and acetylcholine were evaluated in the unpredictable chronic stress (UCS) rodent model in the presence of Consciousness Energy Healing Treated (the Trivedi Effect®) nove…

Transiently Raised IOP Equivalent to That Experienced During Ocular Surgery Causes Moderate Inflammation but does not Affect Retinal Function or Result in Retinal Ganglion Cell Loss in An Animal Model

May 2017 DOI 10.14302/issn.2470-0436.jos-17-1453
Jie ZhangCorresponding author

Purpose: High intraocular pressure (IOP) is known to result in retinal ganglion cell (RGC) loss, both with chronically raised intraocular pressure (such as with glaucoma) and with acute raises in pressure (due to injury or acute angle closure). Because IOP is often raised during ocular surgery, the…

The Advantages of Employing the Immune Response Mediated by Immunoglobulins in Preclinical and Clinical Research: An Essential Review

Sep 2026
Yilkal Tariku BelayCorresponding author

Immunoglobulins, commonly known as antibodies, are glycoprotein molecules present on B lymphocytes and within the bloodstream. They are essential components of the immune response, as they detect the harmful molecules of test compounds and stimulate the immune system to manifest proportional counter…

RETRACTED: Leap into Fetal Surgery; In Utero Placental Mesenchymal Stem Cell Therapy, A Contemporary Approach to Treating Myelomeningocele

Apr 2024 DOI 10.14302/issn.2997-2086.jfs-23-4651
Osama Siddiqui MuhammadCorresponding author

This article has been retracted on April 10, 2025. VIEW THE RETRACTION NOTICE (https://doi.org/10.14302/issn.2997-2086.jfs-25-5857) Myelomeningocele (MMC), a class of spina bifida is a type of neural tube defect. According to the U.S. Centers for Disease Control and Prevention, each year approximate…

Evaluation of Anti-oxidation and Therapeutic Effect of Biofield Energy Healing Based Novel Test Formulation Using TNBS (Tri Nitro Benzene Sulfonic Acid) - Induced Ulcerative Colitis in Sprague Dawley Rats

Feb 2021 DOI 10.14302/issn.2471-2140.jaa-21-3704
Snehasis JanaCorresponding author

The aim of the study was to evaluate the antioxidant potential of Biofield Energy Healing (the Trivedi Effect®) based test formulation using TNBS-induced colitis animal model. Each ingredient of the test formulation was divided into two parts. One part was denoted as the control without any Biofield…

On the Role of Cholecystokinin (CCK) in Fear and Anxiety: A Review and Research Proposal

May 2019 DOI 10.14302/issn.2644-1101.jhp-19-2766
Francesco CrespiCorresponding author

Cholecystokinin (CCK) is found in high concentrations in cortical and limbic structures including the amygdala of rodents, and evidence has been gathered supporting a role for CCK in the neurobiology of anxiety. A variety of animal models have been used to study a central state of fear or anxiety, s…

Developing Cellular & Molecular Biomarkers for Anti-Inflammatory Activities of Probiotic Bacteria in Fermented Foods

Mar 2019 DOI 10.14302/issn.2379-7835.ijn-19-2578
Farid E. AhmedCorresponding author

We present below a mechanistic cellular and molecular approaches for the development of Anti-Inflammatory biomarkersof Probiotic Bacteria in Fermented Foods. Probiotics are live microorganisms that promote human health by counteracting the noxious toxic gut microflora in human intestine, by modulati…

Synthesis of Labeled Rifabutin Dithiocarbamate: A Potential Mycobacterium Tuberculosis Imaging Agent

Mar 2017 DOI 10.14302/issn.2572-5424.jgm-16-1352
Syed Qaiser ShahCorresponding author

In this investigation, Rifabutin dithiocarbamate (RFND) was labeled with Technetium-99m (99mTc) using tricarbonyl technique. The labeled RFND was further characterized in terms of radiochemical purity, stability in saline & serum, in vitro bacterial binding, biodistribution in animal model rats and…

In Vitro Cytoprotection of Resveratrol against H2O2-Induced Oxidative Stress and Injury in Astrocytes

Aug 2016 DOI 10.14302/issn.2474-9273.jbtm-16-1151
Guoqiang XingCorresponding author

Oxidative stress mediated neural cell death is thought to be involved in the progression of secondary cell injury following brain trauma. Agents that can block oxidative stress-related injury could be potential therapies for TBI. Resveratrol, a polyphenol found in plants and red wine, is cytoprotect…

Breast Feeding and Melatonin: Implications for Improving Perinatal Health

Jul 2016 DOI 10.14302/issn.2644-0105.jbfb-16-1121
George AndersonCorresponding author

The biological underpinnings that drive the plethora of breastfeeding benefits over formula-feeding is an area of intense research, given the cognitive and emotional benefits as well as the offsetting of many childhood- and adult-onset medical conditions that breast-feeding provides. In this article…

Search for New Targets of Deep Brain Stimulation for Epilepsy Treatment

Mar 2016 DOI 10.14302/issn.2470-5020.jnrt-15-800
Lili HuangCorresponding author

Although clinical trials in refractory epilepsy are currently carried out, the field of deep brain stimulation (DBS) in epilepsy is still at its initial stage. Little is known about where, when and how to stimulate and what would be the short and long consequences. Animal studies might provide clini…

Ciliary Neurotrophic Factor Activated Signaling Pathways in Retinal Müller Cells

Mar 2016 DOI 10.14302/issn.2470-0436.jos-15-739
Vijay P. SarthyCorresponding author

Ciliary neurotrophic factor (CNTF) is a well-tested, neuroprotective agent that has been shown to retard photoreceptor degeneration in several animal models of retinitis pigmentosa. The molecular mechanisms underlying CNTF-mediated neuroprotection are currently not understood. CNTF could act directl…

Bioinformatic Resources for Diabetic Nephropathy

Sep 2013 DOI 10.14302/issn.2374-9431.jbd-13-226
Amy Jayne McKnightCorresponding author

The number of individuals with diabetes is increasing worldwide and a large subset of those affected will develop diabetic nephropathy. Diabetic nephropathy is the leading cause of end-stage renal disease, has serious health consequences for affected individuals, and represents a major monetary cost…

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