Search results for “clinical”

Evaluation of Recruitment Approaches for the HPTN 052 Clinical Trial of HIV Serodiscordant Couples in Rural Western Kenya

Recruitment of couples is important for study success. The multi-centered HPTN 052 clinical trial was designed to evaluate whether immediate versus delayed use of ART by HIV-infected individuals would reduce transmission of HIV to their HIV-uninfected partners. The objective of this study was to ret…

Demographics, Clinical Profile and Outcome among the HIV Infected Persons Hospitalized in the HAART Era in Barbados.

Background: HAART has resulted in significant decline in morbidity and mortality from HIV. However, it is unclear if the trends have continued in the current HAART era. An understanding of healthcare utilization patterns is important for optimization of care and resource allocation. We examined the…

RETRACTED: Multidisciplinary doctor’s clinical practice, confident and difficulties to diagnose, manage and care for dementia in remote area hospital

Technical Evaluation of Automated Left Ventricular Quantification in Cardiac Magnetic Resonance Imaging: Comparison with Manual Reference Measurements

Background Automated left ventricular (LV) quantification may reduce the manual post-processing burden of cardiac magnetic resonance (CMR) imaging but requires evaluation against manual reference measurements before routine clinical use. Purpose To evaluate automated CMR post-processing for LV quant…

Impact of Shift Work on Heart Health: Do Shift-Working Healthcare Workers Have Higher Cardiovascular Risk Than Non-Shift Healthcare Workers? A Narrative Review

Background: Shift work is unavoidable in continuous healthcare delivery, but whether shift-working healthcare staff carry greater cardiovascular risk than their non-shift colleagues has not been synthesised endpoint by endpoint. Objective: To examine, for each cardiovascular risk factor and each cli…

Use of Stem Cell Growth and Differentiation Factors (Scdsf) in Central Vertigo

The clinical use of SCDSF factors in neuro-degenerative pathologies offers a potential therapeutic opportunity. Our observational study aims to evaluate its efficacy in patients affected by Central Vertigo1. A case series divided into two subgroups, all affected by non-migrainous central vertigo, wa…

Obesity and Type 2 Diabetes Impacts on Late Life Bone Fragility, Falls, and Fractures: A Narrative Review and Commentary

Sound bone health and the ability to respond effectively to unexpected mobility obstacles that heighten falls risks are crucial for mediating many life affirming activities at all ages, but may be impacted adversely over the course of time by multiple factors, such as excess body weight and its link…

An Integrated Systems Thinking-Artificial Intelligence Approach to Advancing Biology and Biomedicine

The complexity of living systems, ranging from cellular networks to organisms to ecosystems, poses a significant challenge to the progress of contemporary biology and biomedicine. Living organisms are complex adaptive systems that are characterized by nonlinear interactions, causal-dynamic feedback…

Cyclic Peptides: Prominent Next Generation Targeted Therapies

Cyclic peptides are expected to play a significant role in the future of drug discovery and development. Their unique properties, such as enhanced target affinity, metabolic stability, and favorable pharmokinetic profiles, make them promising candidates for addressing complex therapeutic targets. In…

From Pelvis to Foot, Part II: A Longitudinal Kinetic Chain Hypothesis for Eversion Ankle Sprains in Athletes

Background Eversion ankle sprains, although less common than inversion injuries, are often associated with greater severity and more complex recovery patterns. Their biomechanical origin remains less clearly understood. Objective To propose a functional, longitudinal kinetic chain model in which ant…

Isolation of Burkholderia cepacia Complex from Pericardial Fluid in a Patient with Lung Adenocarcinoma with Metastasis: A Rare Case Report

Burkholderia cepacia complex was isolated from pericardial fluid in a patient with metastatic lung adenocarcinoma, representing a rare opportunistic pericardial infection. Clinical improvement following targeted antimicrobial therapy supported its pathogenic significance and highlights the importanc…

Maternal Healthcare Utilization and Health-Related Quality of Life among Young Pregnant Mothers Aged 10-24 Years in Eastern Uganda: A Cross-sectional Study

Introduction Young pregnant mothers experience heightened biological, social, and economic vulnerabilities that may compromise health-related quality of life (HRQoL), especially in low-resource settings. Although maternal healthcare service utilization (MHCSU) improves clinical outcomes, evidence li…

Random Forest Classifier for Respiratory Mortality Analytics

Respiratory diseases remain a major contributor to hospital morbidity and mortality worldwide, particularly among elderly patients and individuals with severe pulmonary compromise. Accurate prediction of respiratory mortality is clinically important for triage, resource allocation, ICU utilization,…

Disseminated Mucormycosis Diagnosed by Urine Microscopy in a Patient with Relapsed Acute Lymphoblastic Leukemia: A Case Report

Background Mucormycosis is a rapidly progressive invasive fungal infection associated with high mortality in patients with hematological malignancies such as Acute Lymphoblastic Leukemia(ALL). Early diagnosis is challenging because clinical and radiological findings are often nonspecific, and tissue…

Outcomes of Differentiated Thyroid Cancer Patients Treated with Surgery and Radioactive Iodine at SQCCCRC

Objective To evaluate the treatment outcomes of patients with Differentiated thyroid cancer (DTC) who underwent total thyroidectomy followed by RAI therapy at the Sultan Qaboos Comprehensive Cancer Care and Research Centre (SQCCCRC) in Oman. Methods This is a retrospective observational clinical stu…

From Pelvis to Foot: A Functional Approach to Preventing Ankle Sprains in Athletes

Background Ankle sprains are among the most common injuries in sports, often characterized by high recurrence rates despite appropriate local treatment. Traditional approaches primarily focus on the injured joint, with limited attention to proximal biomechanical factors that may predispose athletes…

Apomorphine Subcutaneous Infusion is More Efficient Than foslevodopa/foscarbidopa Subcutaneous Infusion in the Treatment of Advanced Parkison´s Disease for the Spanish National Health System

Objectives Motor fluctuations and non-motor disorders not manageable by first-line treatments in advanced Parkinson's disease require continuous dopaminergic stimulation strategies such as subcutaneous infusions of apomorphine (APO) or foslevodopa/foscarbidopa (FLD/FCD). A Budget Impact Analysis (BI…

A New Model of Body Composition: Concept and Design Features of the DBA-Model

Indices, based on data such as height and weight in general and in particularly the body mass index (BMI), are often used to assess overweight. However, there is limited capacity to differentiate the amount of fat mass between individuals. This review refers to an anthropometric model called Dahlman…

Diabetic Mouse Delayed Wound Model Following Treatment with the NerveStim™ Neuropathy System

Delayed wound healing in diabetes is characterized by impaired angiogenesis, persistent inflammation, extracellular matrix dysregulation, and peripheral neuropathy. A preclinical study was conducted using a diabetic mouse delayed wound model to evaluate the surrounding tissue of a wound, (its periwo…

Honour and Shame as Moral-Emotional Identity Regulation in Diaspora: An Interpretative Phenomenological Analysis of Young British South Asian Women

Honour and shame are central moral constructs within many South Asian communities, yet their psychological internalisation in diasporic contexts remains underexamined. This qualitative study explored how young British South Asian women (aged 18–25; N = 6) understand and negotiate honour in relation…