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Jul 2017 DOI 10.14302/issn.2639-1716.jn-17-1495
Michael J GonzalezCorresponding author
Diets high in unsaturated fatty acids, especially those containing high levels of linoleic acid, e.g., corn oil, enhance mammary gland tumorigenesis in experimental animals. In contrast, diets high in long-chain polyunsaturated fatty acids such as eicosapentaenoic (EPA) and docosahexaenoic (DHA), e.…
Jul 2017 DOI 10.14302/issn.2379-7835.ijn-17-1636
Peter R. HoltCorresponding author
Adipose tissue inflammation is associated with obesity comorbidities. Reducing such inflammation may ameliorate these comorbidities. n-3 fatty acids have been reported to have anti-inflammatory properties in obesity, which may modulate this inflammatory state. In the current study a 1 gram per day o…
Apr 2017 DOI 10.14302/issn.2572-5424.jgm-17-1482
Morris H BaslowCorresponding author
Canavan disease (CD) is a globally occurring but rare human spongiform leukodystrophy that is associated with inborn errors affecting the activity of aspartoacylase (ASPA), an enzyme highly expressed in oligodendrocytes that hydrolyzes N-acetylaspartate (NAA). Lack of ASPA activity is associated wit…
Aug 2016 DOI 10.14302/issn.2474-7785.jarh-16-1157
Nimmathota ArlappaCorresponding author
Objectives: World has witnessed a considerable increase in the proportion of elderly population.Aging is associated with decreased physical activity and metabolism and thereby the changes in the nutritional requirements of older adults.The objective of this communication was to assess the nutritiona…
Jul 2016 DOI 10.14302/issn.2572-5424.jgm-16-1066
Sanjay HarrisonCorresponding author
Lactic acidosis is a condition commonly encountered in the hospital setting particularly in critically ill patients and is very often used as a diagnostic adjunct when encountering cases of ischaemia or other hypoperfusion states. Despite its use many clinicians have long forgotten the biochemical m…
Feb 2016 DOI 10.14302/issn.2326-0793.jpgr-15-889
Norman E. BurokerCorresponding author
Purpose The endothetal Per-Arnt-Sim (PAS) domain protein 1 (EPAS1) gene which encodes hypoxia-inducible-factor-2 alpha (HIF2a) is a transcription factor that is involved in the response to hypoxia. EPAS1 has been found to have four (rs56721780, rs6756667, rs7589621, rs1868092) simple nucleotide poly…
Feb 2016 DOI 10.14302/issn.2372-6601.jhor-15-896
Vladimir ZaichickCorresponding author
Objectives: Adenocarcinoma of prostate is an internationally important health problem of the man, particularly in developed countries. The aim of this exploratory study was to evaluate whether significantchanges in the prostatic tissue levels of calcium (Ca), potassium (K), and magnesium (Mg) as an…
Jun 2015 DOI 10.14302/issn.2379-7835.ijn-14-479
Johannes ErdmannCorresponding author
Objective: Detailed reports in changes of eating habits especially in elderly subjects with successful weight loss and maintenance are virtually unknown. In this paper we have analyzed the eating habits of 104 obese patients (BMI 37.8±0.3 kg/m2, age range 65 and 84 years) who lost 11.5±0.3kg over an…
Mar 2014 DOI 10.14302/issn.2372-6601.jhor-13-362
Spiros A. VlahopoulosCorresponding author
A narrative review summarizes how fenofibrate influences cancer cell metabolism and proliferation. It reviews PPAR‑α–dependent and independent mechanisms, context‑specific effects, and implications for repurposing studies.
Sep 2013 DOI 10.14302/issn.2374-9431.jbd-13-218
Gregory OxenkrugCorresponding author
The increased association between depression and diabetes mellitus is generally acknowledged. Recent studies suggest that depression leads to diabetes.However, the underlying molecular mechanisms for this association remain unclear.Literature and our data indicate that inflammatory and/or stress fac…
Dec 2012 DOI 10.14302/issn.2326-0793.jpgr-12-100
Shitao LiCorresponding author
Defining protein-protein interactions is essential for understanding the mechanisms by which cells regulate basic functions, such as metabolism, transcription, and signal transduction. Affinity purification followed by tandem mass spectrometry (AP-MS) has application for discovery of new interactors…