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Aug 2019 DOI 10.14302/issn.2572-3030.jcgb-19-2955
Vladimir N PakCorresponding author
This review revisits alpha‑fetoprotein (AFP) and AFP receptor biology beyond their classic role as oncofetal markers. It summarizes signaling, tumor biology, and clinical implications across malignancies, including diagnostic, prognostic, and therapeutic angles. The authors highlight opportunities a…
May 2019 DOI 10.14302/issn.2644-1101.jhp-19-2766
Francesco CrespiCorresponding author
Cholecystokinin (CCK) is found in high concentrations in cortical and limbic structures including the amygdala of rodents, and evidence has been gathered supporting a role for CCK in the neurobiology of anxiety. A variety of animal models have been used to study a central state of fear or anxiety, s…
Mar 2019 DOI 10.14302/issn.2576-6694.jbbs-19-2684
Rajesh K. SrivastavaCorresponding author
Yeast as unicellular organism, has shown multiple application due to exhibition of noble ability in its cells. And engineered yeast has found more suitability in bioprocesses application as well as adverse conditions adaptation. Different types of yeast strains showed their best capability to adapt…
Dec 2018 DOI 10.14302/issn.2379-7835.ijn-18-2501
Paolo MainardiCorresponding author
In the last few years, gut microbiota has been identified to be an essential mediator in health and disease. In fact, it interacts with various organs and systems in the body, including brain, lung, liver, bone, cardiovascular system, and others. Microbiota-derived metabolites such as the short chai…
Dec 2018 DOI 10.14302/issn.2326-0793.jpgr-18-2422
Satyajit PatraCorresponding author
This review summarizes tumor development in p53‑deficient mouse models, discussing tissue specificity, cooperating pathways, and insights into human cancer biology.
Oct 2018 DOI 10.14302/issn.2326-0793.jpgr-18-2312
Mohammad Saad Zaghloul SalemCorresponding author
All aspects of life activities in living cells are mediated/executed and regulated by a vast number of networks, comprising a wide spectrum of components, starting with simple biomolecules and ending with the whole organism, and functioning within a precisely organized tight framework. Proper mediat…
Aug 2018
Alina ParaninaCorresponding author
Journal of Biosemiotic Research is a new periodical devoted to a young, actively developing science. A review of recent scientific publications shows that in the broad scientific space of biosemiotics contemporary questions and "eternal themes" interact, not finding an answer in the private sciences…
Apr 2018 DOI 10.14302/issn.2326-0793.jpgr-18-2004
Pervez AnwarCorresponding author
Human proteome project was revolutionized about 40 years ago with purpose of summarizing whole proteomic data at one place. It was launched after human genome project to map and observe all proteins. The goal related proteomic study is to draft the entire human proteome in disease diagnosis by using…
Apr 2018 DOI 10.14302/issn.2768-0207.jbr-17-1925
Qifeng BaiCorresponding author
Big data research has become popular and exciting studies in almost all scientific fields such as biology, chemistry, epidemiology, medicine and drug discovery. The various systems and platforms produce large amounts of data every day. It will be very helpful for the researchers and workers to deal…
Feb 2018 DOI 10.14302/issn.2832-5311.jpcd-18-1955
Qian-Hao ZhuCorresponding author
Circular RNAs (circRNAs) are covalently closed single-stranded loop RNA molecules with or without protein coding capability. CircRNAs were previously considered to be splicing intermediates or artifacts but are now found to be pervasively expressed in all eukaryotes studied with some demonstrated to…
Dec 2017 DOI 10.14302/issn.2998-4211.jalr-17-1884
Roberto PaganelliCorresponding author
This editorial for the Journal of Alzheimers Research and Therapy outlines persistent questions in Alzheimer biology and care, and highlights emerging tools and study designs. The journal aims to connect mechanistic insight with therapeutic development and practice. It invites interdisciplinary work…
Sep 2017 DOI 10.14302/issn.2575-7881.jdrr-17-1749
Kiran D. BhilareCorresponding author
Though, directed evolution/In vitro evolution has greatly enhanced the applicability of natural biomolecules, there is still a big void in synthetic biology, which could be filled only when we are able to make novel/synthetic functional biomolecules. Terminal deoxyribonucleotidyl transferase (TdT) i…
Jul 2017 DOI 10.14302/issn.2326-0793.JPGR-17-1571
Henrique C. P. FigueiredoCorresponding author
Perkinsus marinus is an intracellular parasitic protozoan that is responsible for serious disease epizootics in marine bivalve mollusks worldwide. Despite all available information on P. marinus genomics, more baseline data is required at the proteomic level. Our aim was to study the proteome profil…
Jan 2017 DOI 10.14302/issn.2572-3030.jcgb-16-1307
Rafael MoralesCorresponding author
Interpreting variants of uncertain significance (VUS) for their effect on protein function, and therefore for the risk of developing cancer, has become a challenge in clinical practice for genetic counselling services. The present work combines structural bioinformatics and systems biology based mat…
Jan 2017 DOI 10.14302/issn.2574-4372.jesr-16-1395
Tetsuro WakatsukiCorresponding author
Calcium (Ca2+) plays a central role in regulating many biological processes in the cell from muscle contraction to neurotransmitter release. The need for reliable fluorescent calcium indicator dyes is of vast importance for studying many aspects of cell biology as well as screening compounds using p…
Jan 2017 DOI 10.14302/issn.2470-5020.jnrt-16-1288
K QuenumCorresponding author
Cerebral aspergillosis is a severe disease most commonly suspected in immunodeficient patients. The objective of this study is to determine the role of surgery in management of intracranial aspergillosis. We report three cases of immunocompetent patients presenting: posteriror fossa aspergillosis, s…
Jun 2016
Mary V. SeemanCorresponding author
Background: There is a growing scientific interest in the phenomenon of earworms, which are melodies that are heard and re-heard despite the absence of an external stimulus. Aim: The aim of this paper is to determine whether understanding earworms can shed light on mechanisms underlying auditory hal…
Jul 2014 DOI 10.14302/issn.2377-2549.jndc-14-edt-1.1
Qian ZhuCorresponding author
An inaugural editorial sets scope and standards for the journal, highlighting emerging areas in chemical methods, materials, and interfaces with biology and energy.
May 2014 DOI 10.14302/issn.2572-3030.jcgb-13-369
Ashraf KhanCorresponding author
Insulin receptor substrate (IRS) 1 and 2 are downstream signaling proteins that influence breast pathophysiology. IRS-1 promotes carcinoma cell proliferation; whereas IRS-2 regulates cell motility, invasion, and glycolysis. Our lab has shown that distinct cellular localization of IRS-2 also plays a…
Feb 2014 DOI 10.14302/issn.2372-6601.jhor-13-346
Chloe E. ClaphamCorresponding author
Targeting cell metabolism is a therapeutic approach which has been used for the treatment of cancers with high levels of proliferation. Inhibition of metabolic processes in cancer cells has shown synergy with current therapeutic options to reduce refractory disease and relapse. In contrast, chronic…