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Jan 2019 DOI 10.14302/issn.2641-5526.jmid-18-2529
Juan Luis Fernández-MartínezCorresponding author
Discrimination of case-control status based on gene expression differences has potential to identify novel pathways relevant to neurodegenerative diseases including Parkinson’s disease (PD). In this paper we applied two different novel algorithms to predict dysregulated pathways of gene expression a…
Jan 2019 DOI 10.14302/issn.2643-0282.imsj-18-2448
Kleber Santiago Freitas e SilvaCorresponding author
Fungal infections increased substantially in the last years, becoming a relevant public health problem. Many of these infections account for high rates of morbidity and mortality. The emergence of resistant fungal clinical isolates have also motivate studies to find new antifungal therapies. Candida…
Aug 2018
Qifeng BaiCorresponding author
Drug design, referred to the fields of pharmacology, biotechnology and medicine, is in silico, in vitro and in vivo assay processes of finding new candidate medications based on the biological targets. The in silicoexperiments of drug discovery are involved in the macromolecular structure databases,…
Aug 2018 DOI 10.14302/issn.2639-1716.jn-18-2208
Gerald J. MizejewskiCorresponding author
Breast cancer (BC) is the leading cause of cancer-related deaths in young to middle-aged women worldwide. Moreover, the survival rate in BC-patients is only 20% when associated with metastatic disease. The high mortality rate observed in BC women with metastatic disease has precipitated a major chal…
May 2018 DOI 10.14302/issn.2832-5311.jpcd-18-2077
Vladimír FarkašCorresponding author
Polysaccharide transglycosylases (PTGs) are a unique group of glycoside hydrolases playing important roles in the formation and modification of plant and fungal cell walls. Their action involves cutting the molecule of the polysaccharide substrate at the glycosidic bond, followed by transfer of the…
Apr 2018
Dongye LiCorresponding author
Heart failure(HF) is a disease with high morbility and mortality. The benefits of current pharmacological and device therapy for survival outcomes of patients with HF are limited. Gene therapy represents a novel promising strategy in treating HF, as it can theoretically normalize the aberrantly expr…
Aug 2017 DOI 10.14302/issn.2474-3585.jpmc-17-1591
Jan ScottCorresponding author
Background: There are relatively few research publications of mental health promotion initiatives for primary school aged children that are based in community rather than educational settings. Aims: To describe developmental frameworks and models of mentoring, coaching and mental health promotion an…
Jun 2017 DOI 10.14302/issn.2329-9487.jhc-17-1536
Md. Kamrul HossainCorresponding author
Over the last few decades, many research works highlighted the role of miRNAs on cardiac diseases. Ischaemic heart disease (IHD) or coronary heart disease is a condition that is mainly caused by atherosclerosis. It has been established that microribonucleic acids regulate many factors that are invol…
Apr 2017 DOI 10.14302/issn.2470-0436.jos-17-988
Ying-Ling ChenCorresponding author
Photorefraction (PR) methods have beenwidely used for pediatric vision screening since the 1980’s. While PR is easy to implement, the accuracy of refractive error measurements in humans has been unsatisfactory, largely due to the variations of intraocular scattering, the retinal reflectance, and pup…
Mar 2017 DOI 10.14302/issn.2326-0793.jpgr-17-1447
Timothy D. HowardCorresponding author
Factors that contribute to the onset of atherosclerosis may be elucidated by bioinformatic techniques applied to multiple sources of genomic and proteomic data. The results of genome wide association studies, such as the CardioGramPlusC4D study, expression data, such as that available from expressio…
Jan 2017 DOI 10.14302/issn.2379-7835.ijn-16-1408
John BukusubaCorresponding author
Despite the agreed global and national stunting reduction targets, Uganda has made very little progress. Understanding context-specific risk factors for stunted growth is therefore pertinent to designing programs to address the problem. A cross-sectional study was conducted in 32 randomly selected v…
Dec 2016 DOI 10.14302/issn.2471-2140.jaa-16-1378
Jie YinCorresponding author
Methionine (Met) is a nutritionally essential amino acid and has been widely demonstrated to improve cellular oxidative balance and mediate oxidative stress. Met targets reactive oxygen species (ROS) directly by being oxidized to Met sulfoxide (MetO) 1. Met can be metabolized to cysteine (Cys) throu…
Oct 2016 DOI 10.14302/issn.2572-3030.jcgb-16-1276
Takuma HayashiCorresponding author
Human uterine leiomyosarcoma (LMS) is neoplastic malignancy that typically arises in tissues of mesenchymal origin. The identification of novel molecular mechanism leading to human uterine LMS formation and the establishment of new therapies has been hampered by several critical points. We earlier r…
Feb 2016 DOI 10.14302/issn.2329-9487.jhc-15-864
Martin Rosas-PeraltaCorresponding author
This article reviews heart–kidney signaling in heart failure, contrasting adaptive and maladaptive pathways. It discusses neurohormonal activation, fibrosis, and emerging therapeutic targets.
May 2015 DOI 10.14302/issn.2379-7835.ijn-14-603
Kenneth LundstromCorresponding author
Epigenetic mechanisms based on DNA methylation, histone modifications and RNA interference have recently showed important association to the development of a wide variety of diseases such as cancer, cardiovascular, metabolic, skin, autoimmune diseases and neurologic disorders. In the context of prev…