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Apr 2020 DOI 10.14302/issn.2470-0436.jos-20-3303
R. ManikandanCorresponding author
The effect of resveratrol, a free radical scavenger, during cataract development was evaluated in the Wistar rat pup model. This study investigated the possible free radical scavenging potential of resveratrol at 40 mg/ kg body wt dose in selenite-induced cataract in rat pups. Intraperitoneal inject…
Mar 2020 DOI 10.14302/issn.2577-2279.ijha-20-3215
O. Atinuke AnjorinCorresponding author
Department of Anatomy and Cell Biology
Since oxidative stress impairs the cardiovascular function, the hypothesis from the present study is that the treatment of paraquat-exposed adult Wistar rats with methanolic extract of Abelmoschus esculentusseed would reduce paraquat-induced cardiovascular damage. Thirty healthy female Wistar rats w…
Jan 2020 DOI 10.14302/issn.2379-7835.ijn-20-3159
Fang-Qiang ZhouCorresponding author
Pyruvate holds superior biomedical properties in increase of hypoxia tolerance, correction of severe acidosis, exertion of anti-oxidative stress and protection of mitochondria against apoptosis, so that it improves multi-organ function in various pathogenic insults. Particularly, pyruvate preserves…
Dec 2019 DOI 10.14302/issn.2574-4488.jna-19-3112
Zeki AydinCorresponding author
Introduction Increased oxidative stress and blunted anti-oxidant mechanisms are important problems in hemodialysis (HD) patients. Reactive oxygen species (ROS) act directly on proteins, leading to the formation of oxidized amino acids. Advanced oxidation protein products (AOPP) are among these subst…
Nov 2019 DOI 10.14302/issn.2324-7339.jcrhap-19-3070
Bechan SharmaCorresponding author
The telomeres existing at the end of the eukaryotic chromosome, play an important role in localization, pairing of homologous chromosomes during cell division and synapsis formation, while telomerase is involved in maintenance of the telomere length. The application of antiHIV-1 molecules particular…
Oct 2019 DOI 10.14302/issn.2574-450X.jom-19-2852
EH RadwanCorresponding author
Obesity can be defined as a condition of abnormal or excess fat accumulation in adipose tissue, to the extent that health may be impaired. Fennel is one of the oldest spice plants which widely grows in arid and semi-arid and due to its economic importance and pharmaceutical industry usage. This plan…
Sep 2019 DOI 10.14302/issn.2577-2279.ijha-19-3026
Abdelmonem Awad HegazyCorresponding author
Background Hypothyroidism is a metabolic disorder affecting the functions of many tissues in the body including the testis. Testis is rich in the polyunsaturated fatty acids content and lacks strong intrinsic antioxidant system making it prone to such oxidative stress. L-carnitine (LC) regulates lon…
Jun 2019 DOI 10.14302/issn.2690-0904.ijoe-19-2792
Manfred NeubergerCorresponding author
In deaths and diseases attributed to tobacco smoke cardiovascular events exceed cancer and respiratory diseases. Second hand smoke promotes the development of arteriosclerosis and can trigger acute changes of endothelial function and blood coagulability. Indoor smoking bans reduced coronary syndrome…
Feb 2019 DOI 10.14302/issn.2374-9431.jbd-19-2613
Eman H. RadwanCorresponding author
Diabetes mellitus (DM) is a chronic metabolic disorder. Streptozotocin is a naturally occurring cytotoxic chemical, particularly toxic to the pancreas and insulin producing beta cells in mammals and induces diabetes. Glimepiride is a second generation sulfonylurea, used as second-line or add-on trea…
Jan 2019 DOI 10.14302/issn.2574-450X.jom-18-2484
Eman H. RadwanCorresponding author
Obesity is associated with a number of serious medical complications, which are often referred to as the “insulin resistance syndrome”. The aim of the present study was performed to investigate the possible interaction between a conventional drug used for management of cholesterol and traditional he…
Nov 2018 DOI 10.14302/issn.2640-6403.jtrr-18-2449
Ebtehal Mohammad FCorresponding author
Methotrexate (MTX) is an anti-metabolite in cancer chemotherapy and is associated with various toxicities assigned to inflammation and oxidative stress. The present study was undertaken to corroborate the therapeutic effects of bone marrow mesenchymal stem cells (BM-MSCs) and adipose-derived mesench…
Nov 2018 DOI 10.14302/issn.2574-4488.jna-18-2443
Wei SuCorresponding author
Renal fibrosis was a chronic and progressive process affecting kidneys in chronic kidney disease (CKD), regardless of cause. Although no effective targeted therapy yet existed to retard renal fibrosis, a number of important recent advances have highlighted the cellular and molecular mechanisms under…
Aug 2017 DOI 10.14302/issn.2690-4721.ijcm-17-1676
Andrew W. Taylor-RobinsonCorresponding author
Malaria is a mosquito-transmitted infectious disease caused by intracellular protozoan parasites of the genus Plasmodium. In the absence of prompt and appropriate treatment contraction of primary infection by a human being often represents a medical emergency since it may progress rapidly to life-th…
Dec 2016 DOI 10.14302/issn.2471-2140.jaa-16-1378
Jie YinCorresponding author
Methionine (Met) is a nutritionally essential amino acid and has been widely demonstrated to improve cellular oxidative balance and mediate oxidative stress. Met targets reactive oxygen species (ROS) directly by being oxidized to Met sulfoxide (MetO) 1. Met can be metabolized to cysteine (Cys) throu…
Feb 2016 DOI 10.14302/issn.2326-0793.jpgr-15-889
Norman E. BurokerCorresponding author
Purpose The endothetal Per-Arnt-Sim (PAS) domain protein 1 (EPAS1) gene which encodes hypoxia-inducible-factor-2 alpha (HIF2a) is a transcription factor that is involved in the response to hypoxia. EPAS1 has been found to have four (rs56721780, rs6756667, rs7589621, rs1868092) simple nucleotide poly…
Jun 2015 DOI 10.14302/issn.2471-2140.jaa-14-616
E.A. MilwardCorresponding author
Age-related macular degeneration (AMD) is responsible for a substantial proportion of severe visual impairment and blindness in people over 50 years of age. Current treatments for AMD are not effective in all patients and a proportion of patients who respond well to the treatment will still eventual…
Jan 2015 DOI 10.14302/issn.2379-7835.ijn-14-606
Michael J. GladeCorresponding author
Telomeres are strings of DNA that are not themselves genes but that extend every chromosome beyond its last gene. Terminal telomeres are sacrificed during every mitotic event in human cells (“telomere attrition”), preserving the functional genome despite the “end replication problem.” However, the “…
Oct 2014 DOI 10.14302/issn.2471-2140.jaa-14-423
L.S. BilbisCorresponding author
There is increasing evidence of the prevalence manifestations of metabolic syndrome worldwide. Metabolic syndrome is a cluster of abnormalities characterized by hypertension, central obesity, insulin resistance, endothelial dysfunction, dyslipidemia and oxidative stress. All these alterations predis…