Protein-protein interactions are the specific physical contacts established between two or more protein molecules, forming the molecular basis of most cellular processes. Through complementary binding interfaces, proteins assemble into stable or transient complexes that carry out enzymatic catalysis, signal transduc…
Protein-protein interactions are the specific physical contacts established between two or more protein molecules, forming the molecular basis of most cellular processes. Through complementary binding interfaces, proteins assemble into stable or transient complexes that carry out enzymatic catalysis, signal transduction, gene regulation, molecular transport, and the construction of cellular architecture. These interactions are characterized by their binding affinity, specificity, and kinetics, and are organized into extensive networks, or interactomes, whose topology reflects cellular function. Their study is fundamental to understanding biological mechanism and to therapeutic development, because many drugs act by stabilizing or inhibiting defined interactions, and aberrant interactions contribute to cancer and cardiovascular and other disease. Experimental and computational tools used to dissect them include affinity purification coupled with tandem mass spectrometry, molecular docking, structural and spectroscopic methods, and bioinformatic network and variant analysis. The research reflected here includes affinity-purification mass spectrometry in mammalian cells, molecular docking studies, bioinformatic identification of proteins implicated in atherosclerosis, proteomic and genomic techniques for diagnostics and personalized medicine, structural-functional analysis of disease-associated variants, and in silico inhibition of microbial proteins. The journal publishes peer-reviewed studies on protein-protein interactions, their structural and computational analysis, and their relevance to molecular mechanism, disease, and drug discovery.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 74 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Nov 2026.
A sample of recent works citing this journal's research on Protein-protein Interactions, linking to each citing work.