Research Topic · Peer-Reviewed

Therapeutic Targeting

Therapeutic targeting is the design and deployment of interventions that act selectively on a defined molecular or cellular feature driving disease, with the aim of correcting a pathological process while sparing healthy tissue. The approach begins with identifying and validating a target, typically a protein, signa…

Curated from this journal's research 📚 8 peer-reviewed articles cited Cited 4× across the literature 🔖 ISSN 3144-7090

Overview

Therapeutic targeting is the design and deployment of interventions that act selectively on a defined molecular or cellular feature driving disease, with the aim of correcting a pathological process while sparing healthy tissue. The approach begins with identifying and validating a target, typically a protein, signaling pathway, metabolic dependency, gene product, or cell population whose modulation alters the disease course. Once validated, agents such as small molecules, monoclonal antibodies, peptides, or nucleic-acid therapeutics are developed to inhibit, activate, or otherwise perturb that target. Common strategies include blocking enzymes and receptors, exploiting metabolic vulnerabilities on which malignant or stressed cells depend, modulating transcription factors and inflammatory regulators such as NF-κB signaling, and interrupting host pathways co-opted by oncogenic viruses. Rational target selection is increasingly informed by structure-based and computational design integrated with in silico, in vitro, and in vivo evaluation, allowing candidate compounds to be screened, optimized for potency and selectivity, and assessed for efficacy and safety. Therapeutic targeting underpins precision and personalized medicine, in which treatment is matched to the molecular profile of a patient or tumor. Its central challenges include achieving specificity, overcoming acquired resistance, managing off-target effects, and translating mechanistic insight into durable clinical benefit across oncology, immunology, and infectious disease.

Research published in this journal

8 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 8 articles above have been cited 4 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Nov 2026.

A sample of recent works citing this journal's research on Therapeutic Targeting, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Journal of Advanced Therapeutic Science (ISSN 3144-7090).

Journal editorial board
Canan HASCICEK · Turkey Dong-Kug Choi · South Korea Feng Ding · China

This page summarises published research for orientation; it is not medical or professional advice.